ࡱ> q` RbjbjqPqP9::'~>>>RHHH8HT"IRBJJ`J"JJJEPEPEP&(((((($hirL->qNNEPqqLJJuyq" J>J&q&rFT6>FJ>J d{H}xj0ۧ0 ۧFۧ>F$EPTUgY s\#EPEPEPLL<^EPEPEPqqqqRRRDCHRRRHRRR  ,{AS Nz ߘT[hQ'`ktf[ċN nxOߘT[hQTNSOeP^ [ߘTۏL[hQ'`ċN0ߘT[hQ'`ċN;N/ffgyߘT/f&TSN[hQߘ(u ߘT-N gsQqS[bRbir(vk'`SvQΘi'Y\ )R(uYvktf[Denxir(v[hQBRϑ ǏΘiċ0OۏLΘic6R0ߘT[hQ'`ċN(WߘT[hQ'`xvz0vcT{t NwQ g͑vaIN0 ktf[[hQ'`ċNvi_TSU\ۏ z N0W,gi_ 1. [hQN[hQ'` (Wktf[f[y [hQ(safe)/fcNySf[ir((Wĉ[vO(ue_T(uϑagN N [NSOeP^ NNuNUO_c[ sS N_w%`'`0ba'`-Nk N NN[c(Sb01_0u0|^TU[Y)STNNu\o(WvqS[0[hQ'`(safety)R/fNyv[v0[(uaIN Nv[hQi_ /fc(WN[c4ls^ N 4OvqSi^_NO bvQqSi^4ls^(W>yO@bcSvVKNQvv[[hQi_0[hQ'`TqSi^[E N/fN N Tv҉^S f TN*N0 2. ScSqSi^4ls^ (W[Eu;mT]\O-N NUO;mR4ON[ z^vqSi'` ~[v[hQsSqSi^/f NX[(Wv0S_cgySf[kirNSugy_c[vscяbeuؚN^c扺N HNُNsS\O:NSf[kir[NSOeP^NuqS[vScSqSi^4ls^(acceptable risk level)0 3. [E[hQBRϑ NScSqSi^v[^vcBRϑ/f[E[hQBRϑ(virtual safe dose VSD)0OY(W~uLvՋ-N _w$vSuscяbvS_NScSqSi^4ls^vSf[kirBRϑsSS\O:NُySf[kirLv\O(uv[E[hQBRϑ0 4. ktf[[hQ'`ċN ǏRir[T[Nv‰[ fgyir(vk'`S\o(WvqS[ [ir(&Tb>e^:W\OQS vQ[ bcQN{|[hQvcagN sS[N{|O(uُyir(v[hQ'`\OQċNvxvzǏ zy:Nktf[[hQ'`ċN(toxicological safety evaluation)0[[E N/f(WNgyir(vk'`SqS['`vW@x N hQbCgavQ)R _T[E^(uvS'` NnxOir(vg'YHev0[u`sXTN{|eP^g\qS['`v҉^ [ir(&TuNTO(u\OQ$Reb[BlN{|v[hQcagNvǏ z0 N0[hQ'`ċN z^vSU\ۏ zSaIN :NNON{|veP^0u`|~vs^aTo}YvsX(ϑ N{|e(WQCSt^MR1\a_Џ(ul_Kbkeg~blQqQkSuNSN{|veP^T[hQ YlQCQMR18N~ S]k&OsV,{mQNVsIl obk^NW Tv 0IlbklxQ 0 vQ-N gmSsQN4ln0zzlalg0ߘTnmI{ebvage020N~RSNeg V0lV0_VI{NNV[_YN;SukSuebN蕄vzl F~6RT^NsQN gkSf[Tv{tlĉ0,{N!kNLu'YbT @w>yO~NmvSU\Tyf[b/gvۏek kSuzl_0RNNLuTVv͑Ɖ YV[T~~HQT6RN gkSf[Tv{tl {tktf[(regulatory toxicology)ۏeQN[(SU\v6k0{tktf[\ktf[vwƋb/g \o(WSf[kirvKmՋSxvz~g^(uNkir{t N2lN{|v-Nk'`eP^qS[SObsX0[mSktf[yS{t6Rzl0gbl$N*NebvQ[0OY VߘTNoir{t@\(Food and Drug Administration FDA)1979t^^TߘT0oirTSYTlHh(the Federal Food Drug and Cosmetic Act FD&CAct) [TySf[ir([hQ'`ۏL{tVE~NmNSU\T\O~~(Organization Of Economic Cooperation and Development OECD)N1982t^^NSf[irT{tl cQNNteWYkt[cWS0o}Y[[ĉ(good laboratory practice GLP)TSf[irb>e^:WMR3ubk'`DevgNOP^ [eSf[ir[L~Nv{tRl0 kSuL?egblTYZNl_lĉ:NQ~ ktf[[hQ'`ċNR/fQvW@x01999t^'k2mVVSuNNSv` (dioxin)ߘiralgNN SbbV(WQvYV[\OQb~ۏSSualgߘTvQ[ sS/fNktf[[hQ'`ċNDe:NOnc\OQvQ0=\{NLuTV1uN?el0~Nm0SS0eS O~v]_ @b[Blv[hQ'`T[ktf[[hQ'`ċNvBlO g@b N T TV9hncT N TegvNRTX[(Wveg6Rv^vkSul_lĉۏL{t FO[Sf[kirۏL[hQ'`ċNtS/fTVv^vkSul_lĉ-NvW,gBl0 NLuTV[Sf[ir(ۏLktf[[hQ'`ċNGWNN{|O(uv[[hQ:NMRc0wS ~[v[hQ/f NSX[(Wv ċNvOnc/fN{|b>yOYcSv[hQ'`0bV[ N Tir(ۏLktf[[hQ'`ċN-N [[hQ'`vBl/fc-NNSNlqQTVl_lĉAQ Nv[hQ cbV>yOSU\0RsN6k@bcSvqSi^4ls^0 bV[Sf[ir(vk'`t[Sktf[[_YN50t^N (WNmQASt^N[ߘT0oTI{f\OǏRekvl_ĉ[ FOdkTNkeۏU\bau\Pn NMR v0R80t^NNTMb gNŏvSU\0}6qbVkSuzlwekZf FO@w9ei_>e0Vl~NmT>yOvSU\ 6RSf[ir([hQ'`ċNSO|Tzl{tS_Nz4x'`vۏU\080t^NNeg bV gsQF~S^NNNSf[ir(vk'`t[ z^Tel ُNeNwQ glĉ'`(THeR0V[_NF~^N gsQvl_ NR:_[YegSf[irv{t0vMRbVُebvl_lĉSO|]ekb_bv^ Ne[U T~kSuL?e蕝Olgbl {twQ g:_6R'`T[He'` bHe>fW [ObsXTONlSOeP^S%c@w͑v\O(u0vMRbV[ev;N gsQl_lĉ g (1) kSu(W1983t^lQ^ 0ߘT[hQ'`ktf[ċN z^(ՋL) 0 1985t^~ǏO ck_lQ^:N[(85)kS2W[,{78SeN](WhQVVQ[e01995t^10g30elQ^N 0-NNSNlqQTVߘTkSul 0 dkl,{Nz:N ߘTkSuhQT{tRlv6R 0NdklMWY kSu萎N1994t^8g10eybQǏ-NNSNlqQTVV[hQ 0ߘT[hQ'`ktf[ċN z^ 0(procedures for toxicological assessment on food safety)GBl5193.1-94v^NN[e0 (2) kSu萌TQN萎N1991t^12gSN 0Qo[hQ'`ktf[ċN z^ 0(toxicologicalproceduresOfsafetyevaluationforpesticides)0dkċN z^ĉ[NQo[hQ'`ktf[ċNvSR0yvSBl TN(WbV3u{vSۏL[hQ'`ċNvT{|Qo0:NMTZP}YQo{v V[b/gvcw@\N1995t^8g17eS^N-NNSNlqQTVV[hQ 0Qo{vktf[Ջel 0(toxicological test methods of resticides for registration)GB 15670-1995 hQĉ[NQo{vktf[vel0agNvW,gBl v^N1996t^1g1ew[e0 (3) 1984t^9g20e(W,{mQJ\hQVNlNh'YO8^RYXTO,{N!kO NǏN 0-NNSNlqQTVoT{tl 0 N1985t^7g1eweL0Ndkv[^v/f kSu萎N1985t^7g1e^v^[ev 0eo[ybRl 0-N [oirvktf[ċN\OQNwQSOĉ[0T(W1988t^kSu萁^ 0eo(o)ktf[xvzc[SR 0 [ktxvzvb/gcQNfnxvBl0 (4) 1987t^5g28ekSuS^NV[hQ 0SYT[hQ'`ċN z^Tel 0(procedures and methods of safety evaluation for cosmetics)GB7919-87 N1987t^10g1ew[e0hQ(uN(WbVuNT.UvNRSYTSeTSYTNT wQSOĉ[N[SYTSeTNTv[hQ'`ċN z^T gsQk'`[el0 (5) 1993t^5gkSuߘTkSuvcwh@bS^N 0ߘTRktf[ċN z^Thel(ՋL) 0 hQĉ[NċNߘTOeP\O(uv~N z^Thel :NOePߘTv{tcOyf[Onc0 (6) 1987t^VRbS^ 0Sf[qSiT[hQ{tagO 0 [Tyfr0fqir( gk0 gPvSf[TR:_{t vQ-N gĉ[Sf[qSiirTuNON^T[ybcNSbSf[irvk'`De(WQvNybeN0 :NNۏNekR:_[T{|Sf[vfv{t kSu萎N1999t^3g6R[NsQNeP^vsQNTv[yb]\O z^ b 0-NNSNlqQTVߘTkSul 00 0SYTkSuvcwagO 00 0OePߘT{tRl 00 0u;mn(u4lkSuvcw{tRl 00 0mk{tRl 0SvQ[l_0lĉ0ĉzĉ[1ukSu萡[ybvߘT0SYT0mSn(u4lkSu[hQNT0mkoBRTmkhVhI{T{|NNSOeP^vsQvNTR:NeP^vsQNT0 YUOۏLktf[KmՋTxvz _{ g%NyOvSU\\ Ne_0RO VdkۏLktf[[hQ'`ċN_{%Nf_f:N͑0NyS:S+RNSf[ir(ċNv_KNcQh13-2 0Nh13-1ktf[Ջvk vQ;Nv:S+RTyrp/f`$XRN[Sf[Rgv^(ua$ir(ۏeQ^:WMR\ONSOxvzb$:_NN"Tk'`KmwƋ0 h13-1 ktf[Ջ{|W 1. %`'`ՋN!kf2bBRϑ a Km[JSpe{kϑLD50 b %`'`utf[SS@S0wT[ib'YI{ 2. N%`'`Ջޏ~f2bkeBRϑ a 3*Ngc~e b 2*Nb2*NN NvՋRirNy^nURir{| c 3*NBRϑ4ls^\ d cgb{|yOHev0~NmHevTNeP^HevI{ ُN\:Nk'`ՋvT[Ջ~gۏL~TċNI{cOS0OY [ߘTmRBR^ccvQReQߘT-NvpeϑQo^cce(uBRϑT(Wߘir-NvSkYuϑY:NsXalgir ^NvQ(W4l0zzlbWX-Nv+Tϑ]NkirR^QvQ(Wzzl-Nvg'YSm^0Vdk(WۏLktf[ċNe ^[yir(ǏTy_ۏeQNSOv[Ecg'YBRϑ\OQ0O0 ( N) (uN{|[Ec扌T^(uvNTb__ۏLՋ N,eg (uNktf[[hQ'`ċNvSՋir^Ǒ(u]NTb^.UFUT N/f~Sf[T NS fNSO[Ec扄v`Q0^S_lav/f (Wte*N[Ǐ z-N@bO(uvSՋir_{/fĉe_SՋir(uNߘT NQ~~vQNk'`Ջ0 (2) Y'YN10 P SۏL NN6kvktf[Ջ0 (3) Q/fLD50(W10 P]Se ^ۏL͑ YՋ b(uSNyelۏL0 1uN%`'`k'`Ջ N\O:N[hQċNvOnc (WۏL NbvW Oktf[ՋTN"ՋT N[agN N1\S[SՋir\OQN[ċN0  N ,{N6kW Ok'`ՋĄyk'`Ջ0zSՋ W Ok'`Ջ;N/fc[zS\O(uۏLKmՋvՋ0NzSՋeg['`hfSՋir/f&T gzS\O(ub\o(WvLv\O(u ۏL[{ S:NN"xvzcOel0W Ok'`Ջv~T_{QS8h~ހTw8h~ހ0uk~ހNSO~ހ0SOQTSOYՋv~TvSR0 ՋyvSb`$~̃zSՋ0 $O[ll̃TsNRir_|SOvՋ(Ames) _eSS TR vQNՋa$\ Ӛ_8hsKm[TӚ~ހgrSOxuSRgb$\ |P[xub_RgT~w8NgrSOxuSRgc$vQNY W Ok'`Ջ0SbV79HGPRTWVzSՋ0>f'`{kՋ0gG4O'`'`{kՋ0 z^YDNAO YTbՋd$ O~xuՋe$wgU{QՋ sS30dU{QՋ YSՋirۏL,{ N0V6kk'`Ջ S NۏLُyՋ0 (WN~Q*NzSՋKNMR HQN~Ąyk'`Ջ0 N Ąyk'`Ջ Ąyk'`Ջvv/fNSՋir(WSOQvĄy`Q0 YgNyYegSf[ir(~8^Y!kۏeQ:gSO vQMR!kۏeQBRϑ\*g[hQmd TN!kBRϑS]~ۏeQ RُNSf[ir((WSOQv;`ϑ\ NeXR dkysay:NĄy'`0S_ gkSf[ir(k!k(WSOQĄyN[peϑT Ąy;`ϑǏ-NkBRϑ sSǏO:gSO_YQsk'`S^vgNOBRϑe :gSO1\SHTsk'`\O(u0Ąy'`v'Y\;NSQNSf[ir(ۏeQ:gSOv^TSOQmd^'Y\0Sf[ir(ۏeQ:gSOv^;N1uir(k!k~N:gSOveQ[ Sf[ir(SOQmd^;N1u:gSOr`TSf[ir(,g'`(@bQ[0 ĄyR:Nir(ĄyTRĄy0ir(Ąy/fϑvSS Sf[ir(ۏeQ:gSOT Sf[ir((WSOQ.Yuvϑmdϑ NSۏeQϑ nXR0Sf[ir(ۏeQ:gSO_wN[vRb~gb_`vSS v^ny/} bRĄy0 ĄyՋ8^Ǒ(uĄy|pelb20dՋl0Ąy|pel/f\gySf[ir( cN[e R!k~NRir ~ǏN[eS YY!k~NT Ygir(hQ(WSOQĄy RY!k~Nv;`BRϑNN!k~N TI{BRϑvk'`vS_SKN YgSf[ir((WSOQN gNRĄy RR!k~N;`ϑvk'`\O(uNN!k~N TI{BRϑvk'`\O(u\ gN[ z^v]+R NĄy'`\ v] z^'Y0Vdk (uĄy|peKegh:yNySf[ir(Ąy'`'Y\ KI{NN!k~N@bvBRϑLD50NR!k~N@bv;`BRϑLD50n KNk sSKLD50 (N)/ LD50 (1)0K\萄vb_`SS0 4. >f'`{kՋTDNAO YTbՋY W Ok'`Ջ >f'`{kՋ/fǏYegir([TsNRiruk~ހgrSOxuS\O(uۏLvzSՋ0@b>f'`{kb>f'`{kzS/f1uNSN-NgNebvMP[|P[buSP[ vgrSOxuS N OS|uS(WS-N-Ne NN_'`uk~ހ~T bQsS|uS(W@w^MR{kNTڀ΀eg{kN0Negڀ΀{kNpeegS fSf[ir(vzS\O(uv:_1_ sYǑ(uNU[̖ :NWpeeg{kNSU[̖ veg{kNڀ΀peh:yzS\O(uv:_1_0 s^GWegڀ΀{kNpeegڀ΀{kNpeSU[̖ pe >f'`zSՋvyrp/fTsNRirNegڀ΀{kNpe:N‰[ch ‰[Rirvb;m`Q el{USfnx N N YBgvNhVY FO NYAmeslupOe SS fĖ'`Rirvuk~ހgrSOxuS NhQWVzS0 DNAO YTbՋ/fDNASSf[Lvir_c$O;N gxW_c$O0eˆ0NTTL]eQI{ T (WTyO YvvSN N ǏRdO Yb Y6RTvO Y$NyelۏLO Y0O Y:g6ROuirSOOcNv[3z[vW Of[yr_0]~fYpeSf[Lvir gv~N";mS SNO Y'YRP[ir(DNA0RNASˆ}v( vN8hWVSuvN\O(u v^SST{|WvDNA_c$O TS/fLvǏ zvN*NwRek0VdkSbDNA_c$OSvQO Y\O:NSf[ir(Lv'`[{ 0 ;`KN W Ok'`Ջ(zSՋ)S9hncSՋirvSf[~g0tS'`(NS[W Oir(\O(u~pv N T v^|Q~SOYTSOQՋNSSO~ހTuk~ހvSR (WN NQ[-N bVyՋۏL$R[0 ~g$Re`$YgvQ-N NyՋGW:N3'` ReĄyk'`YUO GWh:ySՋir_SwQ gLv\O(u d^SՋirwQ gASR͑vN

e_ NۏLvQNyvvktf[Ջa$YgvQ-N$Ny:N3'` S g:_Ąy'` R^NN>e_ Y:N1_Ąy'` R1u gsQN[ۏLċ 9hncSՋirv͑'`TSDdeQϑI{ ~TCga)R _Q\OQQ[b$YgvQ-NNyՋ:N3'` RQ bY W Ok'`Ջ-Nv$NyvQNzSՋ(SbV79HGPRTWVzSՋ0>f'`{kՋ0gG4O'`'`{kՋ0 z^YDNAO YTbՋ) YQ v$NyՋGW:N3'` ReĄyk'`YUO SՋirGW^>e_O(uY gNy:N3'` N:N:_Ąy'` RNN>e_Y gNy:N3'` N:N1_Ąy'` RSۏeQ,{ N6kՋ0c$YgVyՋGW:N4'` ReĄy'`YUO GWSۏeQ,{ N6kNba'`k'`Ջ0 V ,{ N6kNba'`k'`Ջ Nba'`Ջ/fNՋRir(WY!k~NSՋire@b_wvk'`\O(u0 Ջvv`$‰[SՋirN N TBRϑ4ls^gU{Q nx[Rirvk'`\O(u'`(TvhV[ v^Reknx[g'Ye\O(uBRϑa$NSՋir[RirA~kS[NNvxu\O(ub$:Nba'`k'`TLvՋvBRϑ bcO9hncc$:NċNSՋir&T^(uNߘTcOOnc0 ՋyvSb90dU{QՋ0A~kՋ0N"Ջ09hncُ NyՋ-N@bǑ(uvgOeach@b_vg'Ye\O(uBRϑۏLċN0 N"Ջ/fNyfYegSf[ir(ۏeQ:gSOT(WSOQ8T6e0R^NclI{uirlЏǏ zTlS:NN"irvuirlSǏ zvՋ0vQvv/fNSՋir(WSOQv8T6e0R^Tcl^NSĄy'` [~bSvvhV[ :N bba'`k'`ՋvTRiry|cOOnc v^N gek'`N"Nirvb_b0bVcQv ߘT[hQktf[ċN z^ -NBl [NbVR6RvSf[ir( (WۏLg~ċNe \^ۏLN NQyN"ebvՋ`$ÀS8T6ea$Km[@Sm^ {uirJSpg(ۏeQ:gSOvYegSf[ir(1uSOQmdNJS@bve)TvQNRRf[chb$;NhV[T~~-NvR^c$cl(?\0|0ƀAl)0 gagNe SۏNekۏLN"NirvRy0t[0[NVE NYV[]ybQO(uTk'`ċNDekPhQvSf[ir( Sf NBlۏLN"Ջ0[N^\NNSOck8^bRvir(S NۏLN"xvz0 ~g$Re`$Ջyv-NNUONyvgOeachvg'Ye\O(uBRϑ(MNL Nmg/kgSO͑)\NbI{NNSOSDdeQϑv100 P h:yk'`:_ ^>e_SՋir(uNߘTa$g'Ye\O(uBRϑ'YN100 P \300 P ^ۏLba'`k'`Ջb$g'Ye\O(uBRϑ'YNbI{N300 P R N_ۏLba'`k'`Ջ SۏL[hQ'`ċN0 N ,{V6kba'`k'`ՋSbLvՋ ba'`Ջ/f‰[ՋRirgDdeQSՋir@bNuvk'`S^ $\vQ/fۏL'`T NSvk'`\O(uNSLv\O(u gTnx[g'Ye\O(uBRϑ :NSՋir&T(uNߘTvg~ċNcOOnc0@bg/fcՋRirte*Nu}Tgv'YRb~u geSSbQNvՋ0LvՋ/fhSՋirbvQN"Nir/f&TwQ gLvbS$v\O(uvba'`k'`Ջel0 Ջyv(u$Ny'`+Rv'Y Tb\ ۏL$Nt^u}Tgba'`k'`ՋTLvՋ v^~T(WN*NRirՋ-N0 ~g$Re9hncba'`Ջ@b_vg'Ye\O(uBRϑۏLċN0Ygba'`k'`Ջ@b_vg'Ye\O(uBRϑ(MNL Nmg/kgSO͑)\NbI{NNvSDdeQϑv50 P h:yk'`:_ ^NN>e_g'Ye\O(uBRϑ'YN50 P \N100 P 1u gsQN[qQ Tċ ~[hQċNT Q[SՋir/f&TS(uNߘTg'Ye\O(uBRϑ'YNbI{N100 P RSQAQO(uNߘT-N v^6R[eAQϑ Y(WNUON*NBRϑSs gLv\O(u N gBRϑNHe^sQ| R1u gsQN[qQ Tċ N\OQċN0 V0[hQ'`ċN-Nlav q_Tk'`t[T[hQ'`ċNvV }_Y ۏL[hQ'`ċNeQTmdYebV }vr^pb =\SZP0Ryf[0lQck0W\OQċN~0 (N) [vyf['` Sf[ir([hQ'`ċN\ktf[wƋ^(uNkSuyf[ /fyf['`_:_v]\O _N/fNyR '`vRR Vdk NN!j_S[_ _{9hncSՋSf[irvwQSO`Q EQR)R(uVQYs gvvsQDe Bl[He0WۏLyf[v[0 (N) ՋelvhQS ktf[ՋelTd\Ob/gvhQS/f[sVEĉT[[penckvW@x0Sf[ir[hQ'`ċN~g/f&TS` SQNktf[[vyf['` [Q[N[[pencvyf[RgT$Re0YUOۏLktf[yf[vKmՋNxvz Bl g%NyOHevT~NmHevvRg v^QvQ[sX(ϑT6qDnvq_T EQRCga)R _ \OQTtvċN cQy(u0P(ub[hQc扌TO(uvagNNS2[V{v^ :N?e^{t蕄vgTQV{cOyf[Onc0 ߘT[hQ'`vΘiċN ߘT-NqS[bRvktf[ċN:NΘiċNcONW@x0ΘiċNSbqS[nx[0qS[t[0f2ϑċ0OTΘit[(V13-1)0ΘiċNvۏLHQnx[ߘT-NS gTNqS[bR sSqS[nx[ 6qT9hncktf[ċN0kYu4ls^Tf2ϑbDdeQϑċN _QOՋߘTgyr[qS[ir[Θiv'`(0'Y\SvQgN Nnx['`vf0qS[t[/fc[SX[(WNߘT-Nvuir0Sf[Tirt'`V }@b bveP^qS[ۏL['`T[ϑċ0O N,Tktf[ċN0kYu4ls^Tߘm9~gvT|0ǏϑvߘT%{Qir0ߘTmRBR0Sf[algir0_uirI{NߘT[hQ'` gsQvqS[bRGWۏLΘiċN0 NbNQovΘiċN:NOegRNf0 1. [hQDdeQϑvnx[ Ǐktf[Ջ_vpenc Yc0RN {QNSOvkeAQDdeQϑADIfW0 3. Θit[ Θit[/fc9hncqS[nx[0qS[t[Tf2ϑċ0Ov gsQDe [gNyrkN]wvb\o(WveP^qS[SuvS'`ۏL['`T[ϑvċN0ߘTQokYuvΘit[9hncQof2ċ0ONǏktf[ċN(ՋRirvk'`xvz)\OQ0Θit[N,egSb$NR sS_wLvu(Lvir)b N_wLvu(^Lvir) vQ-NLvirvq_T:Nf:N͑0 v[NLvirvΘiċNǏ z ^LvirΘiċNvS_vc ǏRirktf[Ջ sS cgqktf[ċN z^ۏLv%`'`k'`Ջ0Rba'`k'`ՋT nx[ NNuk'`q_TvgؚBRϑ sSe\O(u4ls^(no observable effect level NOEL) \vQ\O:NfW0AmesTGoldI{NcQNO(ug'Y_SBRϑ(Maximum tolerated dose MTD) egh:y~NՋRirvg'YBRϑ dkBRϑSY_wN,ՋRirk'`vb_b0v^NMTD N_wvLvuN~ހ{kN gsQv 8^NOf24ls^ N NO_w~ހ{kN0vMR MTD NvSՋRirNv(uN8^ĉvLvuxvz-N0 1uNktՋ0ߘQokYuTߘTm9ċ0OX[(W Nnx['`V } Vdk(WۏLΘiċNe>fWv Nnx[V }_NQۏS0 Nnx[V }egnN$N*NGP`$ՋRirvSf[irf2q_TS(uNKm[Nvq_Ta$ؚBRϑ4ls^q_TQnx0WNNOBRϑ4ls^vsQ0(W:ONNSOpenc`Q N ُNGP[yrkSf[ir/fl gHev0 Nnx[V }vX[(W\%N͑q_T0Rte*NΘiċNv~g0 TTV:gg[ߘT-NQoT}Qov [hQ'`ċNi FAOWHOQokYuT-^O(JMPR)[ߘT-NQokYuir[hQ'`ċNvvv /fnx[(WNvNuNUO6k NO_w g[\O(uvQovkeg'YDdeQϑ0ċNv;`vv/fN;`vktf[penc:NW@xnx[e\O(u4ls^ v^NTv[hQ|pe(uNnx[ADI0QokYuT-^O(JMPR)Sb$N*NrzvQokYuN[\~ sSFAOQokYu\~TWHOQokYu\~0FAOQokYuN[\~#[gQoO(ue_0QovbRTSf[De0RgQokYOirvel ċ0OQokYuvSTNS(Wo}YQNuNd\OGAP N|ߘ\Oir-NQokYu4ls^ ^SQsvQovg'YkYuPϑ(MRL)

e\'` TMO }:y*vxvz~T'`kYuirvuirHe^nx[vhV[Km[kYuir[hQPϑvkYuirhQ cgqo}Yv}QoO(uĉO(u}QoTvkYuϑpenc0}QoEQRclvOogNSTv}QokYuirRgel0 HQ9hnc@b_0Rvktf[pencnx[ADIf'YN9hncktf[Ջ_0RvMRLpenc0 2. }Qo~T'`kYuirvċN }QokYuSbkSOTvQN"NirkYu0}QobvQN"irNQn'YRP[qQN~TNiry:N~T'`kYuir0Yg;`vkYuir-N~T'`kYuir@b`SvkO N'Y 8^S bNyScSvTkYuir\O:NNh eg6Rg'YkYuPϑ(MRL) S_N~T'`kYuir:N;Ne 1\_{[ُN~T'`kYuirvkeAQDdeQϑ(ADI)fvb6R\O(u ^ǏvKmSsqS[v^nx[gNOeb6R\O(uvkYuϑvSm^0 ߘT-N}QokYuvǏOe'` JECFA:N[N,NveP^ NONu_'Yvq_T FO[ؚ^OeaN@bSuvǏOeS^ _w͑Ɖ0Vdk g_[]wvbSuv gǏOeS\O(uvoirkYuϑOc=\SNOv4ls^ YR }T4Yb[̃ }0 lWVߘTvktf[[hQ'`ċN Џ(uWV͑~b/gb iir~ހ-NvWVbWVGre SQeg ~^ukelceQ0RSY iir~ހvDNA-N O[_gyo}Yvyr'` ُye\Oiry:NlWV\Oirgenetically modified plant GMP 0(ulWVߘT\Oir6RbvߘTy:NlWVߘTgenetically modified foods,N N{yGMߘT @bceQvWVy:NhWV(marker gene)0)R(ulWVb/g]~uNQ gfؚ%{QNfWXR T\ NobRvߘT\OirYl܃}|xQ\ ُ\'Y'Y0N[*gegvߘT^:W gS_SߘTNNvN!ki}T0 lWVߘT[N{|eP^Tu`q_T؏X[(WN/fV:NvMR؏l gYyf[nchfGM\Oir[u`sXe[TGMߘT[N{|eP^[hQe[01uN gNlWVߘT\OirNN,g\OirSf[~b N[hQv T sLvߘTktf['`ċNhQTelv^ N[hQ(uNlWVߘT0dkY lWVߘT؏S_S[YeT&Ot0 N0GMߘTv[hQ'` 1. bu }b'`h_WV Ogene transfer GMߘT-Nbu }b'`h_WVantibiotic resistance marker genes ceQN\uS_uirQ v^(WvQ-Nh OKNlS:Nbõ*h ُ1\ gSq_TS gbu }voHe [eP^ bqS[0GM_uirߘT-NvhWV_N gSTN\uS_uirb| Nv~ހ O0FO/f WV O/fN[agNv N/f_[fSuv0 N4N^ N͑vbu }vxv Tvh_WV NS(uNGMߘT_uir0,g/f;m̃b+T g;m̃vGMߘT Õ*h~Q *gSuzS0SN*N͑/fh_WVv3z['`0 2. \o(WOe'` GMߘT-N_eQveWVˆ}v( gS/fߘTOeS0[GMߘTv\o(WOe'`ۏL%Nu0j0~I{(WߘT-N+TϑSSuSS0 6. ^a?aHe^(unintended effects)OY1ueWVNirSNuvN"r^pbI{0GMߘT-N͑ё^\+Tϑ_NQ0 N0GMߘT[hQ'`ċNSR0elTQ[ ċNGMߘT[hQ'`vW,gSR/fċNߘTbvQbRv[‰yr'` ^@bO(uvlWVb/g,g0[v[hQ'`\ NNONv^v O~ߘTb NOXRegߘTvΘi0 1uNċNch؏ N~N hKmel g_ĉ ~ N FAOWHO^Ǒ(u~Tv0R^vNS*NHhċ[e_0VFDAǑ(uTb__ ?eV{k[~g0 [hQ'`ċNelvtOnc;N/f vNk T I{ T'` $N*Ni_0 kl /fbGMߘT\OirNv^vN,g\OirkegċNGMߘTvv[[hQ'`0ċN^Sb[hQ'`T%{QN*jhc$CJOJQJU^JmHnHuhc$CJOJQJ^Jo(hc$B*OJQJ^Jo(phhc$OJQJ^Jhc$@OJQJRHP^Jo(hc$@OJQJRHP^Jo(hc$OJPJQJ^Jo(hc$CJOJPJQJ^Jo(#hc$5CJOJPJQJ\^Jo(hc$5CJOJQJ\^Jo(hc$OJQJ^Jo(hc$CJ OJPJQJ^Jo(hc$5CJ o( hc$o(02B D f h v " N D 6Z.( !dd` $ & Fda$ }dWD`} dWD`$da$d`!H"#$'*)+,////0F0\00001D1`11d`d$d (dN R`d$d N ` $dPPa$d1112<2L2Z2j2z22222223j3334b4d$d &d N P  $dxa$d&d P `d&d P `d`b44444>5Z55556D6v6888999 99d dxWD` dP`d$d &d N P d$d &d N P `89 9 9999"9$99999|??EEQ|??h@FABEEF*GGHd` $ & Fda$ ddWD`d dWD`dHLII3 d` edP`ekd$$Ifl   r*X f  T T T    t0  64 lal $d$Ifa$VVX>\P\f\]x^^P_\___`X`pbbccd$d &d N P dx$d &d N P ` $dxa$ } dWD` dWD`d`\```aaJbNbpbbcc^giil lll,u0uJuNuduhuxu|uvvww4w8wvwzw||>|@|,.|TVlθ{{#hc$5CJOJPJQJ\^Jo(hc$5CJOJQJ\^Jo(hc$5OJQJ\^Jo(hc$H*OJQJ^Jo(*jhc$CJOJQJU^JmHnHuhc$CJOJQJ^Jo(hc$OJPJQJ^Jo(hc$OJQJ^Jo(hc$H*OJQJ^Jo(0cHddzeffHg^g"hh|kkkll(mmmnrpppprd` dWD` dP`d$d &d N P rsvwwwyTzz|d}}&LX>X.Nr dWD`drJ|>2>p TVlnVj $ & Fda$ dWD`d dWD`d`jڟ>d̠Txڡ>\ȩd$d\a$ $ & Fd\a$ dWDd` dWD`^t´ʴδҴ $d$Ifa$ $dx<a$ dWD` ҴԴ$&HJln"*HJH~L@f|z ǷU hc$PJ\hc$PJ\o(hc$ hc$o(hc$5CJPJo(hc$CJPJ\o(hc$5CJOJQJ\^Jo(hc$OJQJ^Jo( hc$CJo(hc$CJOJQJ^Jo(hc$OJPJQJ^Jhc$OJPJQJ^Jo(4ҴԴڴfZZZZ $d$Ifa$kdz$$Ifl   \<g  W V   t0  64 lalh\\\\ $d$Ifa$kdf$$Ifl   \<g WV t0  64 lal"$h\\\\ $d$Ifa$kdN$$Ifl   \<g WV t0  64 lal$&,:FHh\\\\ $d$Ifa$kd( $$Ifl   \<g WV t0  64 lalHJL\jlh\\\\ $d$Ifa$kd $$Ifl   \<g WV t0  64 lallnlRvh[PPPPPPP dWD`  d<` kd $$Ifl   \<g  W V   t0  64 lal vܽ>"$&(*HJz220  d`d`$da$ $ & Fda$ $`dWD``a$ dWD`hl~~"d<8&:TVx~ $d`a$ $ & Fda$dd`'kvǑ(u I{ T'`Nvf\Nv^v O~NT _N^hf0 GMߘTegnvGM\OirNv^v O~\Oirv]>fWe R]bvGMߘT N[O(uv Tv Ty0dkY؏ gGMߘThQ ُN g N Ta0 ;`KN GMߘT؏YNxvz0_SNSFUTSveg vMR؏l gYyf[nchfGM\Oir[u`sXe[TGMߘT[N{|eP^[hQe[0Q0RbVReQWTOT ߘTvV8f_['YX RQS{tRl N NN~VYvSRNelW,g NSNS0 ߘT[hQ'`ktf[ċN>NO N0zWCQ }Q(u[hQ'`ktf[xvz zWCQ }Sbg0Ȕ0h0000Ք000]00Ҕ00q0e0TqQ17yCQ }0bVzWCQ }wυ0N[ PϑE\NLuMO01uNzWCQ }wQ gryrv5uP[~gTYytS'` @bN(ug:N^l0$\vQNASt^NNeg bVe(uzWCQ }e]OYyQ\OirXN Y\0'YF u 4l;zI{ XNE^^8%N N0pp tTu܃I{ NNXN ؏9eUTy(ϑ0ُ:NzWv^(u_N^vMRof0 Te _NQsNzWCQ }vk'`0~e.sg VNe,g}6qbSNNNsQNzWCQ }SvQSTir~|T8TSOeQ0Y l\[)n@Rirvk'`xvz~g FOzW]xxvg~mSSOeQvk'`S܏guirHe^GW*g~bS0:Ndk (WV[yY ~YShQVzWc^^(u[\~v/ec N ~bNYf[yvzWCQ }Q(uOS\OQ vQ-NkSukt~[zWCQ }Q(uۏLN|~vktf[xvz vv/f:NzWCQ }Q(uv[hQ'`ċNcOyf[Onc0 vMRNNLuVeg w zWCQ }Q(u:NbVR vQNϑ'Y O(ub^ V NSODdeQ:gO_NXY 9hnckSu萁Sv ߘT[hQ'`ktf[ċN z^ [ُ{|Sf[ir(N,BlۏLV*N6kvՋ Te(WۏL%`'`k'` 90)YU{QՋTba'`k'`Ջe BlO(u$NyՋRir0Vdk [zWCQ }ۏLNY Nvktf[Ջxvz0 N %`'`k'`Ջ 1. 7hT Ǒ(u~^:N99%v]xxzW vQ~R:NCe(NO3)3 38.75%0La(NO3)339.24%0Pr(NO3)3 5.30%0Np(NO3)3 15.50%TSm(NO3)3 1.180 2. ՋRirTel eP^̖'`\ SO͑20^25g0'Y ̖0Ė|Q g eP^ SO͑180^240g0\ՋRir cSO͑:gR~ \ k~10S 'Y k~12S(̖0ĖTJS) Y\Pߘ6\eT Ջ~(uĉ[Sm^v]xxzWnm [gq~(u0.00002molv]xxnm~SLpÀgk0LpÀSOyGW:N0.1m110gSO͑ ‰[~oTNhTv-NkhsSRir{kN`Q c[ll{LD50fib _ gvRirÀ|SS Slx ]xxzW[̖'`\ LD50:N1875mg45ZKg 95%SO:S:N1692^2097mgkg0'Y}v LD50:N1832mgkg 95%SO:S:N1578^2126mgkg GW^\NNOk{|Sf[ir(0 N'Y \ v%`'`k'`Ջ~g w LD50GW N\N[ESDdeQzWCQ }ϑv10 P VdkS NZP7)YU{QՋ cktf[ċN z^vBl ۏL NN6kvՋ0 N Ąyk'`0zS'`TN"Ջ 1. Ąyk'`Ջ 1-1. RirWistary'Y}v 0SO͑180^240g0 1-2. elՋMR‰[NhT beP^Rir40S ̖0ĖTJS0 cBRϑXl[ke~SLpÀ~NzW]xxvnm0k4e:NNg gkBRϑ_Y:N0.1LD50 (LD50N1832mgkg) ~KN c1.5 PI{k~pegXgkBRϑ /}yՋ_Y0RQs50%v Rir{kNe;`BRϑ("LD50(n)) 9hnclQ_K EMBED Equation.3 {Ąy|peK0 LD501 :NN!k~ov50%{kBRϑ0 1-3. ~ggk;`BRϑ5.3 PLD50e Rir{kN9S _Ąy|pe>5.0 S:N]xxzWCQ }(W'Y SOQef>fĄy :N1_Ąy'`ir(0 2. AmesՋ 2-1. [Pge 2-1-1. zWPge'lSg0'lSȔ0'lSՋSm^:N0.05~-250mgml 'lSSm^:N0.025~50mgmL mT]xxzONSm^:N0.05^50mgml0 2-1-2. [̃y $O[ll̃~(lx:wW(his-)TAl535 TAl537 TAl5380TA980TAl00qQ5*h c8^ĉelۏL~(lx:wWvt[ Y|O\:1Yvt[ RVP["N1Yvt[ uvrBO Y:wWvt[TSVSsvt[0 2-1-3. W{QWS_|SOv|~ cAmesՋSl6RYˆ}v耉dlW{QW(X̃W{QW)0vB\W{QW0^B\W{QW (uY/lTss|lnm['Y _|SOvv^ c8^ĉelM6RS-9mTm0 2-1-4. 3'`[gqirT4'`[gqir(W^N";mSՋ-N[TAl535 TAl537TAl5380TA98TTAl00 5*Ñ*hR+RǑ(u6-MP ums^03 3NN/lT ck[ }T6-MP:N3'`[gq (WN";mSՋ-NR+RǑ(usxp0TvU02-AAF02-AAFTsxp:N3'`[gq(Wte*NՋ-NGWǑ(uDMSO:N4'`[gq0 2-2. Ջel 2-2-1. pՋlT(W4ltm-NO)nvvB\W{QW-NO!kReQ~37!/caW{Q16\evKmՋ̃*hX̃m0.1ml R(b NR)S-9mTm0.5ml mS ŏ>PeQ^B\W{QW N mSs^>eVST>eNv_6mmvmp̃n~GrNhb-N_ (u@r }8T{SϑSՋ7hTp(Wn~Gr N 37!u[{W{Q48\eT‰[~g0 2-2-2. ceQlT(W4ltm-NO)nvvB\W{QW-NO!kReQKmՋ̃*hX̃m0.1ml RSՋ7hT R(b NR)S-9mTm0.5ml mSŏ>PeQ^B\W{QW N lRs^vOvB\W{QWGWSR^ s^>eVS 37!u[{W{Q48\e‰[~g0 2-2-3. ~g$R[hQpՋlNhKm7hT~GrhTVQs[Ɩ̃=V~:N3'`~gceQlNՋs^vQQsvS̃=0RSVSpe$N PN N v^N gBRϑNHe^sQ|$R[:N3'`~g0 2-3. ~gg0Ȕ00Vy|zWTmT]xxzWvpՋlՋ-N N*Ñ*hGW:N4'`~g0ceQlՋ-N[N*Ñ*hvS̃=peGW\NSVSpev2 P NeBRϑNHe^sQ|0(Wte*NՋǏ z-N 3'`[gq~gSSVS̃=peGW&{T[Bl0 3. \ Ӛ~ހgrSOxuSRg 3-1. PgeTel[7hT:NzW]xxv0Rir:NffyĖ'`\ SO͑25^30g0Ջ~R+R~NzW]xxv400mgkg,200mgkg040mgkg 20mgkg)vS_NzW]xxvLD50BRϑv1501100150T11000N4l:N4'`[gq N50mgkgsxp:N3'`[gq N]xx\OzW]xxv-N]xx9hv[gq0k~(u5S\ ޏ~LpÀ5)Y Y{kMR6\eyTl\y4lN }(4mgkg) i1Y{kTSӚ 0.075MKClnmNOn 1000lRy_ 2uTQx(36"1)V[ N!k zzlr^q Giemsagr l\ NRggrSOxuS0 3-2. ~gӚ~ހgrSOxuS{|W;N geˆ eGr :1Y srgrSO0USSONbc0ˆI{0zW]xxv4*NBRϑ~\ Ӛ~ހgrSOxuSs d200mgkgBRϑ~Y vQYOT~N4'`[gq~vke>fW'`]_(P>0.05) 4*NzW]xxvBRϑ~Nsxp3'`[gq~vk g^8^>fW]_(P<0.001)0}6qBRϑ:N200mgkge Ӛ~ހgrSOxuSseuOPؚ(2%) FOvQ[ N*NBRϑ~(20mgkg 40mgkg0400mgkg)xuSsGW:N1.4% N gBRϑNHe^v~'`sQ| V S:NSՋvzW]xxv*g_w\ Ӛ~ހgrSOxuSsXؚ0 4. \ |P[xuSՋ 4-1. PgeTel[7hT:NzW]xxv0[Rir:NffyĖ'`\}v SO͑25^28g \RirRbV~sS3'`[gq~(sxp20mgkg)4'`[gq~(4l)330 89mgkgN55.13mgkgzW]xxvgk~ dsxp:NyTl\gkY vQ[T~GW|~SLpÀ~o ޏ~~oN)Y0~oTVhT i1Y{kRir SQNOoR~w >eeQv g2mlutv4lv[hV-NjRx N NB\n~Ǐn nmN1000lR y_5^10R _S Nnm QReQ2mlutv4l NvQm`mmGr r^T2uV[0\stGr[hQr^qT (u2% O~gr1^1.5\e (Wؚ P>f_\ N‰[|P[b_` kSRirhg1000*N|P[eg{|P[xub_s0 4-2. ~g gkؚBRϑ~ NOBRϑ~04'`[gq~T3'`[gq~v|P[xub_sR+R:N1.50%01.45%01.39%T3.38%0|P[b_`xub_;N:N4Y hs:Ne0Ib_ e[W0S4YI{0>\xub_\ g\:NSSOShTW0,g[~ghszW]xxv[Ė'`\ |P[exu\O(u sS(W330.89mgkgBRϑ\O(u N Nr^pb\ |P[ck8^SǏ z0 5. 'Y SOQR^T.YuՋ 5-1. PgeTelՋ7hT:NmTzW]xxv0ՋR:N$N~ N~:NN!kLpÀ~ Rir:NSO͑20020gv̖'`'Y 0Nk100gSO͑0.5m1vzW]xxvnmN!kLpÀ Sm^:N200mgml [gq~'Y TeLpN4l 24\eTVR0SN~:NgrU~ Nke1800mgkgBRϑvzW]xxvmNW@xre-N N|^t^'Y _Y1uۏߘkQ*Ng[gq'Y ~W@xre TeVR0N N$N~Rir-NTS3S S00_ >00S \7hT c N T~R+RmTYt o~~SbbSFmT~wzzQQr^q ~ؚ)nppS GW6Rb|r7hT (u-NP[;mSRglKm[vQ-NzWCQ }+Tϑ0 5-2. ~g 5-2-1. *grUzW]xxvv'Y hV~~-N_N+T guϑvzWCQ } N-N+Tϑgؚ0 5-2-2. N!kLpÀ~gS'Y v00_000-NzWCQ };`+Tϑ:N660ppm N[gq~k -NzW+TϑXRgY :N[gqRirv29^156 P vQ!k/fT_0-NzW+TϑXRg\ N:N[gqRirv2^3 P0 05-2-3. ޏ~rUkQ*NgT 'Y 0 0>0-NzW;`ϑN:NDdeQϑv0.607ppm N-NT>-N+Tϑgؚ vQ!k:NT -NzW+Tϑ_NO0 5-2-4. NKm[vQyhV~~eg w zW~ÀS8T6eT ;NR^(W >T N-Ngؚ T-Ng\0zW}(W-NvR^Y FOĄyv^ N%N͑ grUzWCQ }v'Y -NvzW+TϑNk[gqؚ10 P0;`veg w zW~ÀS8T6ev_\ ĄyR_N_1_0  N Nba'`k'`Ջ 1. 'Y Nba'`k'`Ջ 1-1. PgeTelՋ7hT:NmTzW]xxv ~^99.74^99.93%0 Rir:NWistary|^t^'Y 0SO͑60^80g \Rir:gRbN~0k~16S ̖ ĖTJS N~:NW@xre~ NN~R+R:N2mgkgSO͑ 20mgkgSO͑ 200mgkgSO͑ 2000mgkgSO͑mT]xxzWre~0\zWGWSbeQW@xre-N ckSRir100gSO͑vۏߘϑc{(ppm)Sm^0,{N!kۏߘϑ ck100gSO͑10g{ NTSO͑XSۏߘϑvSS 9eSzW(Wre-Nv+Tϑ Rir1uۏߘTn4l US<{U{QmQ*Ng0 ‰[chSb  ,r` uS0@mh uSh hV|peTut~~f[hg0 1-2. ~g 1-2-1. N,r`te*NՋgRir;mRck8^ k gIQl *N+RRirvPaSNur0Ջ~_ge,{2~T,{5~RirT{kNNS0 1-2-2. uTSՋgRirSO͑NvYNXr` FO,{5~RirN14hT_Y SO͑YNs^3zr` 0R,{24hTef>fNON[gq~ ~Rg g^8^>fW'`]_0,{5~s^GWߘir)R(usgNO FO~RgNvQ[T~vke>fW'`]_0 1-2-3. @mf[hg(WՋv,{2 4 6*NgKm[@~ˆ}vTQ@,{f!VP[+Tϑ ~gGWck8^0 1-2-4. uShgNՋv,{2 4 6*NgKm[N@n-Nul No0ƀV l(lv0;`]WS?\ }.l Km[~gGW^\ck8^V0Ջ,{mQ*NgKm[N@n-NSe:gx ,{N~vĖ'`Rir@x>fW0WؚNvQ[T~0 1-2-5. hV|pe,{`S~RirSO͑kf>fNONT~ ~~Rg g>fW'`]_0_ > NzTvhVSO͑ NT~ef>f]_0 1-2-6. ut~~f[hgVRT~RirTASS ~IQ\0\5u\Tkbc5u\hg T~Rir00À0~w8N0S2urzI{~~GW*gyr_'`ut9eS0 9hncRirSO͑SS ߘir)R(us0hV|peS@xI{chGWck8^ S:Ng'Ye\O(uBRϑ:N200mgkg0 2. [TQvNba'`Ջ Ջ(uSO͑1^1.25kgv[TQ16S ̖0ĖTJSRb$N~0Ջ~RirkeN500mgkgBRϑvzW]xxvceQre-NU{Q khTNe qQUmQ*Ng0[gq~Uck8^re0ՋgkhTyRirSO͑ R+RN10203040608024 26hTǑ3@Km@~ˆ}v0@|0@nul No @nƀV07Nl(lv 7Il(lvNS@0Ջ~gTQrUzWCQ }Tߘ2kev0uck8^ @mTyhgchN[gq~vkGWe>fW'`]_01udk SN:N(W6*NgU{QՋ-N 500mgkgBRϑvzWCQ }[[TQ:gSO NNu g[\O(u0 3. O~xuՋ 3-1. PgeTelՋ7hT:NzW]xxv0\SO͑200^290gesNTVgWistar'Y N̖20Ė1vkOT<{NM0N!kenhf\h4SmGrSs|P[:NSU[)Y SU[eghQ|P[v,{N)Y{w0\]SU[̖ Rb N*NgkBRϑ~ sS330.89mgkg 165040mgkgS55.13mgkg~ zW]xxvMb1mgm10NY Z6^16)Yk)Y~SLpÀN!k S3'`[gq~ c0.7mgkg~LegS 4'`[gq~~4l Y Z20)YTY{kRir VRySQ΀ g geY‰xub_ Y20Q0 gˆ0u0Vxub_I{ v^ϑT>\ 6qT\kz΀ v1/3(uBoinsmV[ _Qhg(u02/3~ }grhgxub_ ͑phgV'Y\ g00 gI{S`Q0 3-2. ~gY Zgk SO͑X

f0~f[hN[gq~kP<0.01 -NBRϑ~P<0.05 c:yQk S0Rkirvq_T0 ؚBRϑ~8T6e΀ؚN4'`[gq~(P<0.05) gk~΀NSO͑00>\GWNON[gq~ FONؚBRϑ~gf>f(P<0.05) (W΀ vhg-N Ss ggS NhQ :1YSS NhQ N,{205g:Nf>f ؏4O gvQ[S NhQ N[gq~k ؚ0-NBRϑ~P<0.01NOBRϑ~P<0.050 ΀ Y‰SQhg gk~GW*g_8^0 3'`[gq~-N g8T6e΀vk `ShQ萊Y Z v64.71% ΀ gY‰xub_vk `S83.75% ;m΀-NY‰ gxub_v`S;`;m΀Nv31.5% *gQxub_ xub_v`S16.16%0 N N~gSzW]xxv['Y exu\O(u FO(WؚBRϑ\O(u N [k Sڀ΀NuN[vk'`\O(u0 V ba'`k'`Ջ Ջ(u$Ny'`+Rv'Y \zW]xxv c N TBRϑmeQrerUNt^ ‰[[Rirvba'`k'`TLv\O(u0 N ;`~ zWCQ }(WQN Nv^l^(u XRNNNczWCQ }v_SBRϑ bV[zWv_S0)R(u}YNNLuHQ0WMO FOsQNzWvk'`DebS\\0:NN[zWQ(uv[hQ'`ZPQnxRċN bV[zW]xxvۏLNV*N6kvktf[Ջ sS,{N6k 'Y \ vLD50Km[,{N6kĄyk'`Ջ AmesՋ(WVzSRg) \ Ӛ~ހgrSOxuSՋSO~ހgrSOxuSRg \ |P[xuSՋ(uk~ހgrSOxuSRg)SzWCQ }(W'Y SOQR^T.YuՋ(N"`QRg),{ N6k 'Y T[TQvNba'`k'`ՋT'Y v O~xuՋ,{V6k'Y Nt^ba'`k'`ՋSbLvՋ 0Ǐ NV*N6kvktf[ՋSNnx[zW]xxv/fNOk{|ir(1_Ąy'`ezS'`(SbWVzSTgrSOxuS)~mSS8T6eg_ 8T6eT;N(WQ g{^Ąyexu\O(u FO gN[vڀ΀k'`Nba'`k'`Ջ-N'Y vg'Ye\O(uBRϑ:N200mgkg Sf[ADl2mgkg0 ckN60kgSO͑{ kNkev[DdeQϑS120mg ُ*NPϑV܏܏ǏNNe8^ߘir-NSvDdeQϑ(9hnc iirߘT-NzW+Tϑg@bc{QvkNkeDdeQϑ:N1.75^2.25mg)0Vdk s gvDehf zWCQ }vQ(uSN:N/f[hQv0 N0DSAmlBRvk'`Ջxvz DSAmlBR/fbVgS]xvz@bx6RvNyeWؚHemlBR [MNOllvhb _RTllv9_RN w0Rb6RT4xOWllv\O(u0~Y!kՋf DSAS(uN6R|0sT|0gjxI{Su]NuN NfN_O(uvFlT}vl mlHego}Y0Neb~N'YϑvFlT}vl Te_NMNON|TsT|vb,g0FObVvMR[勧NT\*gZP|~v[hQ'`ċN (WbVvߘTmRBRhQ-N_Neĉ[ g gsQe.s VYvMR\edkymlBR FO gNvQbR{|50ՋgRirSO͑c~X *gNUO-Nkur0Ջ~_ge VR@gRir'YSO‰[ThV GW*gf>futSS0 3. AmesՋ O(u1uVAmesՋ[_ۏvՋ̃*h TAl535 TAl00(xWnbcW)TAl5370TAl538TTA98(x~yMOW)0 cAmesSl6RYW{QW ۏL̃*hyr'`t[TVSRg0 (upՋl(RN NRS-9mTm)[DSAmlBRSvQNyMeSeR+RۏLNՋ͑ YՋN!k k!kZPN*Ns^L7hT Te(uDMSOZP4'`[gq (uLeKQ~gZP3'`[gq0~gTՋ7hT[5*Ñ*hGW*g_w̃*hVS0 (WceQlՋ-N 7hT(uN2uW2upMb0.5mgml02mgml05mgml N*NSm^0(WRN NRS-9mTmagN N N TBRϑDSAmlBR@b_wṽ=VSpeGW*gǏSVSv2 P NeBRϑ He^sQ| f N/f&T~Ǐ_|SOvN";mS DSAmlBRGWezS\O(u0 4. 'Y Ӛ~ހgrSOxuSRg SO͑140^160geP^Ė'`'Y 20S:gRb4~ k~5S0DSA7hTBRϑT~O!k:N0mgkg 80mgkg0240mgkg0720mgkg7hTnNqFl-N Mb10m1kgSO͑v[y 4'`[gqS~qFl0R+Rޏ~LpÀ~o5)Y ,{6)YY{kRir Y{kMRRiryTl\y4lN } BRϑ:N4mgkg0 c8^ĉelSӚ 6RYӚgrSOh,g0kSRir‰[100*N-NgRˆv~ހ U_grSOpexuS{|WTxuS~ހpe {xuSs0 ~gSsgrSOxuS{|W;N geGr :1Y0bs0ˆT_\SO T~KN~ހxuSsl g>fW'`]_0 5. \ >f'`{kzSՋ b^^vSO͑32^42gĖ'`\ 3QS:gRb3~ k~10S ,{N~:N4'`[gq~ ~pFl ,{N N~:NՋ~ R+R~DSAmlBRlnm BRϑ:N80mgkgT800mgkg ޏ~LpÀNhT0Q (ubq+gNMǏv̖'`\ SO͑30^40g Ė0̖N16"1 T<{NM7)Y bcSNyb̖ ޏ~NM5hT0kyb̖ 0RNĖ T<{v,{AS]N)Y i1Y{k0VRySQP[[ hgU_;m΀pe {k΀peT8T6e΀pe ;`@w^pe0v^ cNyR^~!jWegkvQk'`0 ~gĖ'`\ ~NDSAmlBRT*g_8^hs0(WNhTՋg TBRϑ~̖ vs^GWSU[s:N84% 78%T78%0R+R\N*NfgՋ-NTBRϑ~vڀ΀{kNpe/}R cNyR^~Yt0~e]Rg ~gTBRϑ~KNڀ΀{kN4ls^]+Re>fW'`0Yg c N TvNMhTgYt ~gk*NMhTg~]__Nl g>fW'`0 6. Nba'`k'`Ջ 6-1. el SO͑160^180geP^'Y 80S :gRb4~ k~20S ̖0ĖTJS0,{N~:N[gq~ re:N N+TDSAmlBRvnfre ,{N N V~R+Rk)Y~N+T800ppm08000ppm 80000ppmvDSAmlBRre0dkre-N c N TkOmRjˆ}v OՋ~re-Nˆ}v(+TϑN[gq~v T0SՋRir1uۏߘ) ۏ4l0ՋqQۏL N*Ng khTyRirSO͑N!k U_remϑ0(WՋvN*NJSgT N*NgehgN'Y v@~ˆ}v0~~ހpe }v~ހ;`peSRpe0@n7Nl(lv0Ջ-NgKm[N'Y |O-N|+Tϑ v^ZPN?\-NnSO['`Ջ0Ջ~_ge k~S12S (̖0ĖTJS)e4YY{k yShV͑ϑ0 _ > ~w8NSP[[(u10%2uV[ ZPut~~f[hg0 6-2. ~g 6-2-1. SO͑ re)R(uste*NՋRirl g{kN0ؚBRϑ~RirSO͑Xba N[gq~vk g>fW'`]_ؚBRϑ~re)R(us_NOPNO ُNSO͑X`Qv&{ FO~f[Yte>fW'`]_0 6-2-2. @mf[hg~g(WՋ N*Nge ؚBRϑ~Rir@~ˆ}v+TϑN[gq~vk Ė gؚ^>fW'`]_ ̖ g>fW'`]_m]~ހkfW0FOT~~~ހT}v~ހpeGW(Wck8^VKNQ @n7Nl(lvvKm[~g(WTBRϑ~KNGWe]_ 6-2-3. |-N|+TϑKm[@wre-NDSAmlBR+TϑXR 'Y |O-N|cQϑNXR ؚBRϑ~N[gq~vk gؚ^>fW'`]_0 6-2-4. ?\-NnSO['`ՋTBRϑ~'Y ?\nSO['`ՋGW:N4'`~g0 6-2-5. hVSO͑kSO SO ̖'`'Y v>SO0SO0SOkfW'`]_0 6-2-6. ut~~f[~gTBRϑ~ՋRirv0_00>000~w8N P[[GW+gut9eS0 7. ڀ΀k'`Txu'`k'`Ջ 7-1. elNSO͑190^270g̖'`'Y}v NĖ'`'Y}v 36"2 T<{NM0kenhfZP̖ 4SmGrg g&T|P[ NSs|P[KNe:NSU[)Y0\U[ :gR:NV~ DSAmlBRvBRϑR+R:N0mgkg080mgkg 800mgkg SNLeKQ~gS4'`[gq~ BRϑ:N0075mgkg N'Y Y Zv,{7^16)Ykeޏ~~SLpÀ~o0(WSU[v,{007012016020)YySO͑ v^ cSO͑te~oϑ0NU[g,{20)Yi1Y{kRir VRySQP[[ U_ĞSOpe0;m΀pe0{k΀peS8T6e΀pe0Nhg;m΀Y‰ gexub_ y΀N͑0Km>\00΀v͑0\12;m΀N(uBoninlmV[ ZPQxub_hg SY12(u }~grv^OKNfS YZPxub_hg0 7-2. ~g 7-2-1. [U[ SO͑Xvq_T d3'`[gq~YT~U[ SO͑Xe>fW'`]_0 7-2-2.  ['Y ڀ΀Svq_T0 N TBRϑDSAmlBR['Y ΀NX[;meq_T d3'`[gq~Y TBRϑ~΀ vSO͑  >\S΀v͑N4'`[gq~vkGWe>fW'`]_0 7-2-3. [΀ TgSߏvq_T ؚBRϑ~΀ gT Sߏv~vRsXR FOe~f[aIN03'`[gq~΀ gS NhQhs:N$NJSbg*gTbT NhQHTtvr N4'`[gq~k]_>fW 7-2-4. [΀ xub_svq_T0TՋ~GW*gSs\ TQ0Q02 0w0 gˆ0YnI{0TՋ~T4'`[gq~GW*g0iI{xub_ 3'`[gq~ g6S΀ hs:NT0lr wS g/_fI{xub_0 8. DSAmlBR(W}v|-NkYuϑvKm[ S]z-NO(uDSAmlBRv}v|7hT100g(u/lNcS2!k Tv^/lN(W4ltm N%cS\ lyeQHQR`͑vhvQ %cr^/lN0110!pp4\e (WdnhVQQtS0y͑0ZPs^LKm[ TeZPՋBRzz}v[gq0,gl@b_V6es:N93.14%0(W6R|]z-Nk(T6R|SeRDSAmlBR20g Q|s:N13% vS_k100g|-N+TDSAmlBR0.0154g Ջ-N|7hTcSDSAmlBRvs^GWk#n͑kՋBRzz}v7hTvs^GWk#nؚ͑0.0004g GP[/lNnQirhQ/fmlBR RDSAmlBR(W|-NvSkYuϑ:NReQϑv2.6%0  N ;`~ DSAmlBR:Nؚx0lxxv YTir0VY{|f'`{kՋgG4O'`'` {kՋ z^YDNAO YTbUDS Ջ0 3.1.2.5 O~xuՋ 3.1.2.6 wgU{QՋ30dU{QՋ0YSՋirۏL,{ N0V6kk'`Ջ S NۏL ,gՋ0 3.1.3 ,{ N6kNba'`k'`Ջ  90dU{QՋ0A~kՋ0N"Ջ0 3.1.4 ,{V6kba'`k'`[SbLvՋ 0 3.2 [ N TSՋir bk'`ՋvSR 3.2.1 Q^\bVRevir(N,BlۏLV*N6kvՋ0yr+R/f[vQ-NSf[~gc:y gba'`k'`0W Ok'`bLv'`SbNϑ'Y0O(uV^0DdeQ:gOY _{ۏLhQV*N6kvk'`Ջ0 3.2.2 Q^\N]wir(c~Ǐ[hQ'`ċNv^AQO(u vSf[~gW,gv TvMuirb{|e_SՋir(uNߘT NQ~~vQNktf[Ջ0Y'YN10 P SۏeQ NN6kktf[Ջ0QLD50(WNvSDdeQϑv10 P]Se ^ۏL͑ YՋ b(uSNyelۏL0 4.2.2 W Ok'`Ջ 9hncSՋirvSf[~g0tS'`(NS[W Oir(\O(u~pv N T v^|Q~SOYTSOQՋNSSO~ހTuk~ހvSR (W3.1.2.1 3.1.2.2T3.1.2.3-N@bRvW Ok'`Ջ-N bVyՋ 9hncN NSR[~gۏL$Re0 4.2.2.1 YvQ-N NyՋ:N3'` Rh:ySՋir_SwQ gW Ok'`\O(uTLv\O(u N,^>e_SՋir^(uNߘTkۏLvQNyvvktf[Ջ0 4.2.2.2 YvQ-N$NyՋ:N3'` NwgU{QՋ>f:ySՋirwQ g>fWvk'`\O(u N,^>e_SՋir(uNߘTYwgU{QՋ>f:y gSuvk'`\O(u R~RekċNT 9hncSՋirv͑'`TSDdeQϑI{ ~TCga)R _Q\OQQ[0 4.2.2.3 YvQ-NNyՋ:N3'` RQ b3.1.2.4-Nv$NyW Ok'`ՋYQ v$NyՋGW:N3'` RewgU{QՋT O~xuՋ/f&T>f:y gk'`Nxu\O(u GW^>e_SՋir(uNߘTY gNy:N3'` (WwgU{QՋT O~xuՋ-N*g gf>fk'`Nxu\O(u RSۏeQ,{ N6kk'`Ջ0 4.2.2.4 YVyՋGW:N4'` RSۏeQ,{ N6kk'`Ջ0 4.2.3 wgU{QՋ (WSBlۏL$N6kk'`Ջe wgU{QՋ*gSs gf>fk'`\O(u ~TvQNTyՋsSS\OQRekċNՋ-NSs gf>fk'`\O(u $\vQ/f gBRϑ-S^sQ|e RQۏNekvk'`Ջ0 4.2.4 90dU{QՋ0A~kՋ0 O~xuՋ 9hncُ NyՋ-N@bǑ(uvgOeach@b_vg'Ye\O(uBRϑۏLċN SR/f 4.2.4.1 g'Ye\O(uBRϑ\NbI{NNvSDdeQϑv100 Ph:yk'`:_ ^>e_SՋir(uNߘT0 4.2.4.2 g'Ye\O(uBRϑ'YN100 P \N300 P ^ۏLk'`Ջ0 4.2.4.3 'YNbI{N300 PR N_ۏLba'`k'`Ջ SۏL[hQ'`ċN0 4.2.5 ba'`k'`SbLv Ջ 9hncba'`k'`Ջ@b_vg'Ye\O(uBRϑۏLċN SR/f 4.2.5.1 g'Ye\O(uBRϑ\NbI{NNvSDdeQϑv50 P h:yk'`:_ ^>e_SՋir(uNߘT0 4.2.5.2 g'Ye\O(uBRϑ'YN50 P \N100 P ~[hQ'`ċNT Q[SՋirS&T(uNߘT0 4.2.5.3 g'Ye\O(uBRϑ'YNbI{N100 P RSQAQO(uNߘT0 4.2.6 eDnߘT0 YTMevneI{(WՋ-N Ջ7hvg'YReQϑN, NǏrev5% bmSOՋ7hg'YSvSm)irReQϑN N0Rg'Ye\O(uBRϑ:NNvSDdeQϑvĉ[ Ppee RSN~TvQNvk'`Ջ~gT[Eߘ(ubn(uϑۏL[hQ'`ċN0 5 ۏLߘT[hQ'`ċNeQvV } 5.1 NvSDdeQϑdN,NvDdeQϑY ؏^QyrkTOeaNY?Qz0U[YSؚDdeQϑN 0 5.2 NSODe1uNX[(W@wRirNNKNvye]_ (W\RirՋ~gc0RNe ^=\S6eƖNcSՋirTS^vDe YLN'`c扌TaYNEecI{0_?aSՋSOQvN"De[N\RirՋ~gc0RNwQ g͑aIN0(WnxO[hQvagN N SNQ cgq gsQĉ[ۏL_vNSOՋߘՋ0 5.3 Rirk'`ՋTSOYՋDe,g z^@bRvTyRirk'`ՋTSOYՋ|~}6qN g_[U tS/fvMR4ls^ N@b_0Rvg͑vDe _N/fۏLċNv;NOnc0(WՋ_0R3'`~g N~gv$R[mS0RSՋir&T^(uNߘTe Q~gv͑'`TBRϑ-S^v^|0 5.4 1uRirk'`Ջ~gc0RNe tNRir0Nvy^\T*NSOKNvuiryr'`]_ N,Ǒ(u[hQ|pevel NnxO[Nv[hQ'`0[hQ|pe8^:N100 P FOS9hncSՋirvtS'`(0k'`'Y\0N"yrp0c扄vNV0ߘT-NvO(uϑSO(uVI{V } ~TQX'YbQ\[hQ|pe0 5.5 N"ՋvDeN"xvz/f[Sf[ir(ۏLktf[ċNvN*N͑eb V:N N TSf[ir(0BRϑ'Y\ (WN"ebv]+R__[k'`\O(uq_T_'Y0(Wk'`Ջ-N SR N^=\ϑO(uNNwQ gv TN"_T!j_vRiry|egۏLՋ0xvzSՋir(W[RirTNSOQ8T6e0R^0clTuirlSebv]+R [N\RirՋ~gkcknx0Wc0RNwQ g͑aIN0 5.6 ~TċN(WۏLgTċNe _{(WSՋirS[NSOeP^ bvqS[NSvQSv gv\O(uKNۏLCga0ċNvOnc NN/fyf[ՋDe NNS_evyf[4ls^0b/gagN NS>yOV } gsQ0Vdk @wevcy _S~_N N T0@w`Qv Ne9eS yf[b/gvۏekTxvz]\Ov NeۏU\ []ǏċNvSf[ir(ۏL͑eċN \OQev~0 [N](WߘT-N^(uNvS_evir( [c扺NۏLAmLuf[gwQ g͑'YaIN FO__N_BRϑ-S^sQ|ebvS`De [NevSՋir( RSO`RirՋTvQNՋxvzDe06q sSO gN[teT=\vRirՋDeTNRN{|cvAmLuf[xvzDe 1uNN{|vyeT*NSO]_ _N_\OQOk*NN[hQvċN0@b~[v[hQ[E N/f NX[(Wv09hnc NPge ۏLg~ċNe ^hQbCgaTQ[ES0NnxOS%cSՋirvg'YHev NS[NSOeP^TsX bg\qS[vMRc N\O(u~0 hUSMO QߘTkSuvcwh:gg0%{QNߘTkSuxvz@bTYef[:gg-NNNߘTktf[]\OvUSMOT GWS9hnc 0ߘTkSuhUSMO{tRl 0 c,g z^ۏLktf[Ջ cQ3u ~ gsQUSMOST MbQwQՋbJT03ubJT1uS_0Ww0v^0ꁻl:SN~ߘTkSuvcwh:ggR[ S_0WkSuL?e蕡[8h kSuߘTkSuvcwh@b[gT bkSukSuvcwSSTYHh0 DRf ,ghQ1ukSukSuvcwScQ0 ,ghQ1ukSuߘTkSuvcwh@b0-NV2;Sf[yf[b%{QNߘTkSuxvz@b#wI0 ,ghQ;NwIN4b[0HTw0_Kf^0Ng`ga0 ,ghQ1ukSuYXbb/gR_SUSMOkSuߘTkSuvcwh@b#ʑ0 DU_N -NNSNlqQTVV[hQ GB 15193.2-94 ߘTktf[[[d\Oĉ Good laboratory practice for food toxicology 10;NQ[N(uV 00,gĉĉ[NߘTktf[[[(Sb[Rir?b)vBl0 00,gĉ(uN~kSuL?e蕤S gDe N)RNd\O0hg0ntSO{Q0 5.1.20kyՋTKmϑňn^OX[U_ U_^Sb 5.1.2.10yňnv Ty 5.1.2.206R S[SWSh_ 5.1.2.306e0Reg 5.1.2.40/T(ueg 5.1.2.505un[n 5.1.2.60~b~ 5.1.2.70gяh[!hQeg0 5.1.30kyՋTKmϑňnvd\OffN^YUOX[ v^^eOO(u [ňnS^1uybQNNy]\OvNXTd\O0 5.1.40ňnNUORQsw bO(u NS_ b~gSu b1uh[SvQNel$R[ g:we ^\PbkO(u ۏLOtv^U_YHh0Yg/fKmϑňn ؏^~h[!hQTe0Wp v^1uchHh#N{t gchHh^NHQ_0RybQ0 7.2.30U_TDe^\OYu$Nt^ FO^Ɖ`QwQSOQ Y(uNHhNɋ cOl_OncvU_TDe gsQ\*gybQveSe0eNThvU_TDe RS^0R5t^0 80 ՋbJT 8.1 [[@b[bv]\O^ ghQbvՋbJT0ՋbJT^Qnx [‰0WHՋ~gS@b g gsQ`Q0 8.20ՋbJT^SbY NQ[ 8.2.10[[v TyT0W@W Ջvwbkeg 8.2.20~NvՋbJTz^S 8.2.30ՋbJT^hfux 8.2.40hUSMO Ty 8.2.50hTvcTƋ+Rh_ 6e0Reg 8.2.60ՋelT z^ 8.2.70DeRg@b(uv~f[el 8.2.80Ջ~gT~ 8.2.90#NY T @b gvQNSNhvNXTS{tNXTvY T 8.2.100[ՋbJT g8h#Nv gsQNXT~{ TSeg 8.2.110;`bJT^1uՋ#N~{ Tv^lfeg0 8.2.120;`bJTO9ebeEQe ^1uՋ#N# fnxO9ebeEQvR fSV ~{ Tv^lfeg0 90 sX 9.10[[vsXagN^nvQhKm]\OvBl0 9.20[[^ǑSS_vceNO_0Ro}Yv{t0 9.30[(uTS^_irYt^n gsQĉ[TBl0 100[RirNSRir?b 10.10[Rirv?b eBl 10.1.10[Rirv?b e^R_:Nrzv^Q{0Sb]\ONXTfcmo Rirr{Q[ m7Rmk[ rePυ[ WePυ[Tyhu[0|O0al4l0(uǏWe0Rir8\SOT^ir^ g[hQYtce0 gyrkBlv[Rir YẽRir eyrkuSSORir ~|RirT GW^ g&{Tyr[Blv^Q{Y %Ne\'`ir(0 OgVP[SwQ g N qS[vir() _{ gۏLyՋvyr+RRir[b:SW N2sXalg0 10.1.30Rir[e^ go}YvbclΘňnTc4lS0[QmQbIQm g2 02kTM)n2[I{e0 10.1.40+s0r04sI{'YW[RirvA~k[b[[^ gS_vЏR:W0W S`vNQbؚXTSB\蕄ve N2Rir80 10.1.50wQ gN[ĉ!jv[Rir[^Q{ hTV\^ g20mkSu:S0 10.20 N,Rir?bv{tBl 10.2.10Rir?bv)n^Ocv[R`[ k)Yv)n^v] NǏ2^4! T{|Rir[)n^vBl/f18^25!0 10.2.20[Qv[n^N40%N80%:N[0 10.2.30^MQؚsjV c6RjV(W60dBNQ v^MQXlvr^pb0 10.2.40Rir?bQ N^ g_8^SmpvlsT ;N1uRirclirNuv(lsT(vQSm^^c6R(W20mg/kgN N)0 10.2.50Rir?b^OcteP [QRir<{wQ NǏ[ k<{RirSpe NǏY0 10.2.60Rir?bQybk8Tp0 10.2.70Rirr{Q[Q N_>enNՋesQvBgir0 10.30 Rir{tBl 10.3.10Rir1uA~kRir?bb1uYUSMO-eQe _{8h[Rir/f&T&{T gsQ{tBl(Ty0RirI{~I{)0 10.3.20@b gNYLuec6eۏvRiry v^[vQeP^rQ\OQċN \[vQ‰[3d nxck8^TMb_Y[0 10.3.30eQRir_{1u~NN# ۏL{vTQYtU_0SbRirpeϑ0'`+R0SO͑V0O~egn0^\0y0Ny0t^I{0 10.3.40(uNxvzvRir gp`S_vh(Y:RW[0rx03h03zT[I{) x vzg k*NRir<{ N_{ gU_aSGr0 10.3.50Y{kvck8^T[Rir^SeQRir[ v^\O&{TBlvYt0[ g%N͑k'`(SbLv'`)ir(S~dkYtvRir^Se>enĉ[v:W@bv^ۏLqk0 10.40 kSu2bBl 10.4.10[RirvhuTuuvc6RSYt 10.4.1.10QYeg[Rir\~Ǐ3dN Nvyhu N2 OguvOeQ0Y‰eu_(_e\Ov^v[[hg4'`)eۏeQr{QA~k[0 10.4.1.20ߘTktf[xvzMR ORireNUOuu v^ORirMQSq_TxvzvvS[evV }0Yg(WxvzǏ z-N Rirc扆N NuuNV } guRir_{y Y gv^Nlu Nq_Txvz S[RirۏL[ub[uvlu0vQʋe0[RirluvybQ0lu@b(uoT0ceSluveg gU_v^OX[0 10.4.1.30RirSuuu{kN^SeۏLut8\hbvQN[[hg \OQʋe cQYta0S_RirSu Ogue SR NhQk0?bK\0(uwQ0<{g0We0c=^I{_{ۏL{_^mk0Rir[\NkeMbO(u0_ebJTՋ#NS;N{0 10.4.1.40[RirSup'` OguAmLe ^zsS Nb[Rirh[-N_ TeǑS%Ne(WQXevhQ g N[Ǐ$N*Ng0nNNO)nPυ^Q SS_^OX[g02bkΑ 0fk0Sf[oTTQovalg0 10.4.2.20Mre_{OSevkSu[hQ _e[gNbRۏLmkYt0 10.4.2.30ere04lg0[rvY0[r_{Qυ(4^8!) e,܃_{mQ ~fr^TQ(u0 10.4.2.40[Pp0S 0BR NS_0cǏ gkoirvre l gmkqSvQNRiriRYOvre NU{QRir &TRf_wuub{kN0 10.4.2.50^O~Rirnm EQvn(u4l n4l_{&{TGB 5749vBl ~4lv(uwQN[OckSu 4lt[em7RTmk 2bk5X^Xb4l{Ǐ'Yo4l0 10.4.2.60(uNRirvreSn4l[gRg NO]wvSq_Txvzv SSX[(WNُNreTn4l-Nvalgir NǏ-N@bP[v4ls^ ُNRgDe\O:NSYDeOX[0 10.4.30 (uwQkSu 10.4.3.10Rir<{gSD^\YO(u[k_{7Rmmk YUX[>e0 10.4.3.20kXeegn^&{TBl _emkYt0 10.4.3.30[NnU{|Rir (kX)ekhT\fbc N!k(eN!k) v^nm^v N,k2^4hTmkN!k _ekhTmkN!k0 10.4.3.40<{gk)YnmN!k _eۏL7Rm0mk0 10.4.3.50Rir?bQY0Lhb00Wb^keۏLnkbTdm0 10.4.3.60 gkiryr+R/fk'`:_0 gLv\O(uvre (W[~_ge_{Seqkv>ev[hV d\Ov(uwQ^\OmkYt0 10.4.40]\ONXTkSu2b 10.4.4.10Rir?bQ gN(uvc0=^0KbWY0I{ ]\ONXTۏQRir?b_{fbcُNN(uc@w N,`Q N khTbcmN!k yrk`Q NebcmTmkYt0 10.4.4.20c扨RirKNMR0T^mKb(_emk) $\vQ(WZPǏnmkSu mMROTNS Tec$Ny N TvRirb$NyN NSՋirI{ef^mKb0 10.4.4.30]\ONXT g{^aQe^4bSi ^=\ϑMQQ\vcc扨Rir0%N͑aQbvQN Og'`uuybkۏeQRir?bv0Ruuua0@b g[NXTveP^rQYgq_T0R[(ϑ _{T NN~ gsQNXTGlb0 10.4.4.40esQ}YRir?b蕗z (WYtRir0_sQ<{e^2bkRir8 gRir8e _{1uS_NN#Ucv^\OQYt0 00DRf 00,ghQ1ukSukSuvcwScQ0 00,ghQ1ukSuߘTkSuvcwh@b0WSN;Sf[b0Ym_lwkSu2uz#wI0 00,ghQ;NwINhgΏ0fegy0lΘ|i0uUx0YO:_0 00,ghQ1ukSuYXbb/gR_SUSMOkSuߘTkSuvcwh@b#ʑ0     PAGE  PAGE 308 ΘiċN 1qS[nx[ 2qS[t[ 3f2ϑċN 4Θit[ Θic6R 1Θiċ0O 2[V{ bċ0O 3[V{ b[e 4vcwT Yh ΘiOo`NAm Risk Communication V13-1 qSiRg NRsQ|v~gV x$&*,<8&(:TVx"""""#B#F###r%v%~%%%%&&<&>&@&B&X&\&&&+ +/00QPQvnnppshc$@OJQJo(j hc$EHU$j1WC hc$CJKHUVaJo(jhc$U hc$H*o( hc$PJo(hc$5CJ\o(hc$5CJPJ\o( hc$@o( hc$\o(hc$ hc$o(: "#<$f$$$%T&&'2'L''() +&+b,T-./2/~1d`dd` dWD` $d`a$~133N677::|:`;; =(=J===n???t@\AAB4CC8DLFpF$da$d`dpFIIJKKFLjLLL0QPQjTTUV@WX`YBZ[0\^x^X`aa dWD`d`da`dxdBRZHPhc$CJaJo( hc$aJ hc$aJo(\lnܔ.0TZDFtvޗln"DLܡ$8>@VXjlrtvΣУ󹯹hc$0J5\aJ0o(hc$0JCJaJ0hc$0JCJaJ0o(hc$hc$5CJ\aJo(hc$CJaJhc$5CJ\o( hc$o(hc$PJaJ hc$aJo( hc$aJ@*,ҤԤ(*԰ְ,0"(>B  fhnr VX "Z\^`bfhlnrtxz hc$0Jjhc$0JUhGjhGUhc$OJQJ^Jo(hc$ hc$o( hc$CJ o(OXZ\^`dfjlprvx $&`#$a$ hh]h`h&`#$dd>@BDT\^x|;ʹ͟͟ hc$CJo(hc$5B*CJ\phhc$B*phhc$5CJ\o(hc$5B*CJ\o(phhc$5B*CJ\o(phhGhc$h@0JmHnHu hc$0Jjhc$0JU 0@BDR\z|d`WD,`$a$-WD`-WD+`70&P 18P4. A!"#$%SO $$Ifl!vh5*5.5.5.5#v*#v.#v:V l t0  655T5 /  /  / / 4al$$Ifl!vh5*5.5.5.5#v*#v.#v:V l t0  655T5 / / / 4al$$Ifl!vh5*5.5.5.5#v*#v.#v:V l4 t0  655T5 / / 4alf4$$Ifl!vh5*5.5.5.5#v*#v.#v:V l4 t0  655T5 / / 4alf4$$Ifl!vh5*5.5.5.5#v*#v.#v:V l t0  655T5 / / 4al$$Ifl!vh5*5.5.5.5#v*#v.#v:V l t0  655T5 / / 4al$$Ifl!vh5*5.5.5.5#v*#v.#v:V l t0  655T5 /  / /  4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/  / 4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/ / 4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/ 4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/ 4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/ 4al$$Ifl!vh55W5V5#v#vW#vV#v:V l t0  655W5V5/ /  4alKDd $J  C A? "2ޝMk`!ޝMkHD @2Oxcdd``f 2 ĜL0##0KQ* WMRcgbR qfĒʂT @_L ĺE^0:Y@V8ȝV ZZ<  f22 afhVe, !/k @!|>0?'@Cܯ<3pa`kjd W&0;0s]N{`fxjA.p,CtA``Ĥ\Y\ * 6y_)  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~  a  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`Root Entry  F g{ Data WordDocument 9ObjectPool d{ g{_1129787827Fd{d{Ole CompObjiObjInfo  FMicrosoft ʽ 3.0 İ DS Equation Equation.39qb?: "LD 50 (n)LD 50 (1)Oh+'0 (Equation Native ~1Table SummaryInformation( DocumentSummaryInformation84 T ` lx4 ʮ \ڶѧеӦ a Normal.dottianer3Microsoft Office Word@Ik@$N6@ pi՜.+,0 X`lt| aheH   FMicrosoft Office Word ĵ MSWordDocWord.Document.89qN@N cke $1$a$$CJKHPJ_HaJmH nHsH tH$A@$ ؞k=W[SOFi@F nfh>??,@AAA9BsBCsDD%E[E>FMFFFGGH8H|HH*I+I6I7IRJ^J+K5KKL2LKLfLyLLLLLMMDM`MMMzN.PPPPPPRST:UMV`VaVeVgViVjVmVqVuVyVzV|VVVVVVVVVVVVVVVVVVVVV6WHWW|XX)YYY[ZZG[[\\\\\$\%\=]]]^^S___`W`k```Uaanb ccd?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`k L c  .7Vckykkkcmnn|oopppq7qqqruw*w0wxDxxyy^zzzzz@{{{U||7}Z~^c5ʆ 6YŊB,xAz7bǒkJ\f0) ÿET  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`;a*urn:schemas-microsoft-com:office:smarttagschsdate<X*urn:schemas-microsoft-com:office:smarttagschmetcnv XH.0004.0154.1.5011.251.5101001101212014015150160171801899198419851987199419951996220200200120022005200620072202402527028290330374404256607708809!DayFalsegHasSpace IsLunarDate IsROCDatekglmmmMonthNegative NumberType SourceValueTCSCUnitNameYearaGA7);8<8aGA37;8<8aGA37;8<8aGA7;8<8aGA57;8<8aGA17;8<8aGA17;8<8aGA.7&;8<8aGA7;8<8XF=D2:8B8CEXF9D:8B8CEXF>D:8B8CEXF9D$:8B8CEXF9D#:8B8CEXF?D:8B8CEXF9D:8B8CEXF9D#:8B8CEaGA7;8<8aGA7;8<8aGA7(;8<8aGA7+;8<8aGA7;8<8XF6D*:8B8CEXF@D/:8B8CEXF6D*:8B8CEaGA7;8<8XF6D*:8B8CEaGA7(;8<8XF9D):8B8CEXF9D&:8B8CEXF9D:8B8CEXF9D :8B8CEXF?D:8B8CEaGA7;8<8aGA7;8<8aGA7(;8<8aGA7+;8<8XF9D4:8B8CEXF9D :8B8CEXF9D :8B8CEXF9D:8B8CEaGA7;8<8aGA7;8<8aGA7(;8<8aGA7+;8<8aGA7.;8<8aGA7/;8<8XF=D:8B8CEXF9D':8B8CEXF=D0:8B8CEXF6D :8B8CEXF6D:8B8CEXF9D":8B8CEXF6D,:8B8CEXF9D:8B8CEXF9D:8B8CEXF9D :8B8CEXF6D,:8B8CEXF9D:8B8CEXF9D:8B8CEXF?D:8B8CEXF9D-:8B8CEXF9D,:8B8CEXF9D:8B8CEaG A7;8<8aG A7;8<8aG A7(;8<8aG A7+;8<8aG A7.;8<8aG A7/;8<8XF9D%:8B8CEaG!A7;8<8aG!A7;8<8aG!A7(;8<8aG!A7+;8<8XF9D :8B8CEXF6D :8B8CEXF9D:8B8CEXF9D :8B8CEXF9D:8B8CEXF9D:8B8CEXF9D:8B8CEXF9D:8B8CEXF9D :8B8CEXF9D:8B8CEXF=D0:8B8CEaGA 7);8<8aGA 7);8<8aGA 7);8<8aGA 7);8<8XF?D:8B8CEXF6D+:8B8CEXF6D$:8B8CEaGA 7);8<8aGA 7);8<8aGA 7);8<8aGA 7);8<8 E #$%&'(, 0fghk|7 a "!$!6! "*"""""#$$e%%%%%%%&&&&&&,&-&;&M&_&j&k&}''''((1*3******;+K++,#-'-8---m2n2p2q22`3s458*9e99:::;;<&==^>_>M?c???,@@RBrBDZEQFFFGGG>>>????+@,@AAAAAA8B9BrBsBCCrDsDDD$E)EZE[E=F>FLFQFFFFFG GGGH#H7H