MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C48430.EEC41120" 此文档为“单个文件网页”，也称为“Web 档案”文件。如果您看到此消息，但是您的浏览器或编辑器不支持“Web 档案”文件。请下载支持“Web 档案”的浏览器，如 Microsoft Internet Explorer。 ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿

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单击此处编辑母版= 6631;题样式
单击此处编辑母版ă= 91;本样式
第二级
第三级
第四级
第五级
‹&= #26085;期/时间›
‹&= #39029;脚›
‹#›
------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/master03.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADVwEAAAYAHAAAAAAABAAAAAMBCAAFAAAACwIAAAAABQAAAAwCeQChAAMAAAAeAAcAAAD8 AgAAzP//AAAABAAAAC0BAAAIAAAA+gIFAAAAAAD///8ABAAAAC0BAQAOAAAAJAMFAP///////3gA oAB4AKAA////////CAAAAPoCAAAAAAAAAAAAAAQAAAAtAQIABwAAAPwCAAD///8AAAAEAAAALQED AAQAAAAnAf//HAAAAPsC7v8AAAAAAACQAQAAAIYAAAAxwaXK6QAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAEAAAALQEEAAQAAAAuARgABAAAAAIBAQAFAAAACQL/MwACEwAAADIKIwAQAAgAAAC1 2squy8TVwhIAAAASAAAAEgAAABEAAAAEAAAALgEAABwAAAD7AhAABwAAAAAAvAIAAACGAQICIlN5 c3RlbQAAAAAAAAAAAAAYAAAAAgAAACA5FQCoAwAABAAAAC0BBQAEAAAA8AEEABwAAAD7AvH/AAAA AAAAkAEAAACGAAAAMcGlyukAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAABAAAAC0BBAAEAAAA LgEYAAQAAAACAQEABQAAAAkC/wAAAhMAAAAyCj0AIwAIAAAAu/nS8rHttO8PAAAADwAAAA8AAAAO AAAABAAAAC4BAAAEAAAALQEFAAQAAADwAQQAHAAAAPsC8f8AAAAAAACQAQAAAIYAAAAxwaXK6QAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEAAAALQEEAAQAAAAuARgABAAAAAIBAQAFAAAACQL2 CAgCDQAAADIKPQBeAAQAAAC197/YDwAAAA4AAAAEAAAALgEAAAQAAAAtAQUABAAAAPABBAADAAAA AAA= ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/master02.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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 &= #39029;眉
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第十四章=
基因表达调控 =
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= 2522;因表达概念：
    贮存着生物体遗传= 0449;息的基因经转录和= 翻译成蛋白质的过程。
基因表达的时间性= 5306;
生物体的不同= 发育阶段；细胞的生= 8271;、增殖、
分化、= 衰老及死亡等不同阶= 7573;
不同的组织细胞发挥= ;不同的生理功能
基因表达的空间性= 5306;
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一、基因表达的= 方式
` 组ৎ= 4;性表达（Constit= utive expression):
•     = 看家基因(housekeeping genes):基= 2240;的表达是持= 2493;性的，不受调控的Ӎ= 0;
•        如= 5306;组成机体的= 结构蛋白= ；三= 2679;酸循
•        = ;        环中的= 代谢酶等。     
诱导和阻๮= 3;表达：
基因的表达受= 调节物的诱导或阻遏= 2290;
 如：&= #21442;与DNA修复的酶类；某些代= ;谢酶，
        = ;     肌动蛋白等。=
<= b>
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四、基因表达调= 511;的生物学意义
（一）适应内外= 环境的变化
（二）维持个体= 生长，发育，增殖，= 0998;化
  蛋白质是生物功能的= ;直接执行者，在特定<= span style=3D'font-family:SimSun;mso-fareast-font-family:SimSun;font-size:133%'= >的时间和空间表达特= ;定的蛋白质是满足上= 述功能需要的保障之= ;一。
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（一）基因表达= 的多级调控
（一）DNA水平
 = 基因丢失；
基因扩增
基因重排；
  甲基化修饰；
染色质的结构状态
（二）RNA水平
转录水平调控<= /b>；
RNA的转录后加工；
mRNA从核内向胞浆转运；= ;
mRNA稳定性
（三）蛋白质水平
翻译过程；
翻译后加工；
蛋白质的稳定性
五&#= 12289;基因表达调控的基Ĉ= 12;原理
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二、基因转录激= 963;调节基本要素
1. 特异的DNA序列
2. 调节蛋白
3.DNA-蛋白质，蛋白质= -蛋白质相互作用=
4.RNA聚合酶
如启动序列，操纵序= ;列，Pribno= w盒，GC= 序列等
如阻遏蛋白，激活蛋= ;白，CAP，转录因子等
改变DNA的结构和RNA聚合酶的功能
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第一节 原核生物基因表达的&#= 35843;控
•研究原核生物的基因表达调控模式= ;可以为探索更复杂的= ;真核细胞基因表达调控机制提供重= ;要的线索，对基因工程也有重要的指导意义= ;。
•
•
•
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一、细菌代谢酶= 0340;诱导
葡萄糖=
乳糖
细菌合成代谢葡萄糖的酶类
细菌合成代谢乳糖的酶类
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二、操= 纵子= (operon)<= i>的结构与功能
Inhibitor gene<= /b>
P&= #13;
S1&= #13;
S2&= #13;
S3&= #13;
启动子
结构基因1，2，3...
O&= #13;
操纵基因
=
<= b>Promoter
Operator gene&= #13;
<= b>Structure = gene
调控区
结构基因
 = 805;纵子
表达阻<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;font-size:117%; color:#3333CC;mso-color-index:5'>遏蛋白
   =
结合RNA
聚合酶
 结ࡧ= 2;
阻遏"= 507;白 <= /span>
表达功能蛋白
=
?&= #13;
I&= #13;
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  三、基因表达调控= 0340;方式: 负调控
启动子
结构基因1，2，3...
操纵基因
调控区
结构基因 =
操纵子
诱= 导= 型
阻= 遏= 型
变构 =
变构 =
阻遏蛋白变构失活 =
阻遏蛋白变构激活 =
  无活= 615;的阻遏"= 507;白
辅阻遏
  物
<= span style=3D'font-family:SimHei;mso-ascii-font-family:SimHei;mso-fareast-font-= family: SimHei;font-size:133%;mso-special-format:lastCR;display:none'> =
阻遏物= 基因
<= ![if !ppt]>=3D"文本框:
ߐ= 4;种方式
阻遏蛋白
诱
导
物
乳糖操纵子为代= 4920;
色氨酸操纵子为= 0195;表
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file:///C:/85899A54/14.files/slide0011.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
三、基ࢰ= 0;表达调控的方式：正调控
启动子
结构基因1，2，3...
操纵基因
调控区
结构基因 =
 操纵子 =
(一)、
转录因= 376;
 
(二)、
转ô= 05;因子
变构 =
转录因子变构激活 =
3D"文本框:
信号 =
分子
  无活= 615;的
    转录因子
<= ![if !ppt]>=3D"文本框:
ߐ= 4;种方式
转录因= 376;
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四、乳糖操纵= 376;的工作原理：
1.负#= 843;控方式
<= b>P
<= b>Z
<= b>Y
<= b>A
启动子
分Š= 99;代谢乳糖= 0340;三种酶基因
O
操纵基因
调控区
结构基因 =
阻遏蛋= 0333;
乳
糖= 3;
变构 =
阻遏蛋白变构失活 =
阻遏蛋= 333;
乳糖操纵子（Lac Operon= ）
<= b>I
阻遏物基因
阻遏蛋= 333;
Z:β-半乳= ;糖苷酶
Y:乳糖ి= 9;透酶
A:转乙຋= 2;基酶
表达
不能表达
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------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0013.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
四、乳糖操纵子= 340;工作原理:2. 正调控
<= b>P
<= b>Z
<= b>Y
<= b>A
启动子<= /b>
分෉= 9;代谢= 乳糖的ߍ= 7;种酶基因
O
操纵基= 240;
= 3;
= 3;
调控区<= /b>
结构基&= #22240;
 
= 3;
3D"椭圆:
CAP
变构
CAP变构激活
3D"椭圆:
cAMP=
CAP
乳&#= 31958;操纵子
  CAP= 位点
  (<= b>Catabolite <= /span>
   <= b>Activator
<= b>   Protein site)
CAP
CAP: 代谢物激活蛋= 0333;
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四、= 乳糖操纵子&= #30340;工作原理：
2. <= span style=3D'font-family:LiSu;mso-fareast-font-family:LiSu;font-size:82%;color= :#FF0066'>正调控 <= /span>
*   
<= span style=3D'font-size:88%;visibility:hidden'>]
•
]<= b>
•
细菌优先利用葡萄糖作为&= #33021;源
 = 6377;葡萄糖： <= /div>
= cAMP = ;
= CAP无活性
不促进转录
无葡萄糖： <= /div>
= cAMP = ;
= CAP有活性
促进转录
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乳&#= 31958;操纵子调控方式的Ĕ= 04;较
负调控=
正&#= 35843;控
调节= 蛋白        = ;          阻遏蛋白        = ;    CAP=
变构= 物        = ;         别乳糖，乳糖=         cAMP
与变= 构物结合        = ;     无活性        = ;   有活性
基因= 位点        = ;            &n= bsp; O基因         CAP= 位点
结合= 于基因位点        基因关闭      基因开放
未结合于基因位点<= span style=3D'font-family:"Times New Roman";mso-ascii-font-family:"Times New Ro= man"; mso-fareast-font-family:SimHei;font-size:150%'>    基因开放      基因关闭
不与变构物结合        = ;  有活性        = ;   无活性
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五、<= /span>色氨酸操纵子= 的工作原理&= #65306;=
        1. 阻遏物介ë= 48;的负调控（主要）
•<= b>
•
trpE
<= b>trpC
= Trp 阻遏
蛋白基因
启动子=
操纵
基因
   前导序列
  （= leader）
 = 4928;减子（attenuator）
    色氨酸生物合成
酶系基因
trpD
Trp阻
遏蛋白
色氨酸
  = 1464;构
Trp<= span style=3D'font-family:YouYuan;mso-fareast-font-family:YouYuan;font-size:83%; color:#FF3300'>阻遏
蛋白
有活性
Trp<= span style=3D'font-family:YouYuan;mso-fareast-font-family:YouYuan;font-size:83%; color:#FF3300'>阻遏
蛋白
色氨酸
无活性
Trp阻
遏蛋白
体现节省原则
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    = 五、色氨酸操ಫ= 7;子= 的工作原理：
 2.衰= ;减子介导的负调= 控
原核生物转录终止的种类：
= 1. 依赖ρ因子的转录终止
       ρ因= 子与新合成的= RNA单链poly C结合，= 促进转录产物从转录= 2797;合物中释= 放出来，终止转录。= ;
依赖ρ因子
不依赖ρ因子
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2. 不依赖ρ因ड= 6;的转录终止
         转录产物形成富&#= 21547;= GC 配对的发夹= 2467;构及其后面富含UA配对的序Ò= 15;，使<= span lang=3DEN-US style=3D'font-family:"Times New Roman";mso-ascii-font-family:= "Times New Roman"; mso-fareast-font-family:SimHei;font-size:150%;mso-fareast-language:ZH-CN'>= RNA聚合酶失活，并使新&#= 21512;成的= RNA易= 从转录复合物中释放&#= 20986;来，终止转录。
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= 五、色氨酸操纵&= #23376;的工作原理
2.衰减子介导的负调= 控
•&= #13;
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   前导序列  （= leader）
 衰减子（attenuator）
  
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序列 2
序列 3
序列 4
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两个相<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;color:#9A3300'>= 邻的色<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;color:#9A3300'>= 氨酸密= 码子
衰减子结构 <= /div>
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= 五、色氨酸操纵&= #23376;的工作原理
2.衰减子介导的负调= 控
•&= #13;
•
   <= /div>
序
列
2
序
列
3
 1
色氨= 酸（trp）缺乏时
核糖体
序列4
核糖体停留在
序列1色氨酸
密码子处
序列2和3
配对形成
发夹结构
序列3和4
无法形成= 3;
衰减子结构
继续转录
合成trp的
mRNA
trpń= 67;构基因
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= = 0116;、色氨酸操纵&= #23376;= 0340;工作原理
    2.衰减子<= span style=3D'font-family:LiSu;mso-fareast-font-family:LiSu;font-size:109%; color:black;mso-color-index:1'>介导的转录= 终止
•&= #13;
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（= 2）细菌内色氨酸（= trp）充ห= 5;时
= 核糖体
核糖体占
据序列1和 <= /span>
序列2
序列3和4
形成
衰减子结构
 转录
 终止！
核౻= 8;体顺利通
过ॴ= 7;列1色ૐ= 8;
酸भ= 4;码子处
序列2
序
列
3
序
列
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A= UAUUAU= UUUUUU
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第二= 节  真核生物基因表达= 0340;调控
一、= 真核基因组结构特点
1.真核基因 = 452;结构庞大
2. 单顺反子
3. 重复序列
4. 基因不连续性
人类：30亿= bp
一个编码&#= 22522;因转录生成条mRNA，<= span style=3D'font-family:SimSun;mso-ascii-font-family:SimSun;mso-fareast-font-= family: SimSun;font-size:117%;color:#3333FF'>经翻译生&#= 25104;一条多肽链。
外显子被内含子= 分隔
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二 、 真核生物基因表达调&#= 25511;的特点
（一）RNA聚= ;合酶
（二）活&#= 24615;染色体结构变化
（三）正&#= 24615;调节占主导
（四）转&#= 24405;与翻译分隔进行
（五）转&#= 24405;后修饰、加工
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种类
转录产物
 RNA聚合&= #37238; Ⅰ
RNA聚合酶 Ⅱ
RNA聚合酶= Ⅲ
45S  rRNA
hnRNA，snRNA
5S  rRNA、tRNA
45S是18S、5.8S和28S rR= NA的前体
= 真核细胞的RNA聚合酶
         RNA聚合酶 Ⅱ= 催化转录的基因<= span lang=3DZH-CN style=3D'font-family:SimSun;mso-fareast-font-family:SimSun; font-size:150%;mso-fareast-language:ZH-CN'>称为<= span lang=3DEN-US style=3D'font-family:SimSun;mso-fareast-font-family:SimSun; font-size:150%;color:#FF3300;mso-fareast-language:ZH-CN'>Ⅱ类࣌= 2;因 <= /span>
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染色质结构与基= 因表达
 
 
与DNA的= 3;
结= 1512;能力
下= 8477;
= 基因的
= 转录活性
DNA去甲基&= #21270;、
增&#= 24378;子和某
些= 蛋白质因子
染色质
结构松散
= 基因的
= 转录活性
  = = 组蛋白被= 磷酸化= 、
= 甲基化= 、 乙酰化<= /b>
= 等修饰
  真核&= #32454;胞的染色质结构&= #26159;调节基因表达= 的物理因素。
 结构<= /b>松散的区域= ，基因的转录活性高。
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= 真核生物RNA聚合酶Ⅱ= 转录的
基因结构与功&= #33021;
•   =
•
<= b>
其= 0182;调
控= 0803;件
<= b>
增= 4378;子
或= 3;
 沉默子
CAAT盒= 3;
   GC盒  
<= b>
TATA <= /div>
 盒
<= b>
结= 6500;基因
+1
调&#= 33410;基因表达水平
决定基&= #22240;表达的
时空特&= #24322;性等。
激素，金属= ;离子，
小分子化合= ;物等
反应元件。= ;
决定基&= #22240;
表达的&= #22522;
础水平<= /b>
<= b>  与RNA poly II
 结合&#= 65292;决定转录
起始点&= #30340;精确定位
使转录
增强或
减弱
维持基本的表达= 水平
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------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0034_image284.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhLAAMAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAMAAwAo AAYAgAAAADNm/wIZhB2ny+0a4pt0xYuz3rz7D0oAVpWlaKZHAQA7 ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0035.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
（二）= 顺式作用= 0803;件
   （cis-acting element）
定义：
<= b>  能与特异性转录= 因子结合，以决定= 转= 录的起始位点<= /b>、转录效率及转录的时ి= 4;= 特异= 性的DNA序列。
包括：
<= b>    启动子（promoter），上游启动= 子序<= span style=3D'font-family:SimSun;mso-ascii-font-family:SimSun;mso-fareast-font-= family: SimSun;font-size:150%'>列（UPS or UPE），增强子= （enhancer），沉默子（= silencer ），= 及各种因子的= 反应元件等。
------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0036.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
1. 启&#= 21160;子
 GC盒
  
TATA 盒
结构基因
+1
      决定基因表= 达的基础水平 = = Sp1, NF1, P1, ……
=  = 9982;RNA poly II
 结合，决定转= 录起始点的精= 确定位。
CAAT盒
  
上游启动子序列（= UPS）
-25
-35
-70
-80
-110
确保转录౹= 4;确而有效地起始的DNAॴ= 7;列
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R0lGODlhAwARAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAgAC AA0AgAAAAAAAAAIEjI+pWQA7 ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0036_image313.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhAwARAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAgAC AA0AgAAAAAAAAAIEjI+pWQA7 ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0037.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
2. 增强子
•
•
•
•&= #13;
•     
•     
•     
能增强启动子活性的DNA序列。
特点：
= 1. 能远距离增强启= 1160;子的活性；
= 2. 在启动子的上游和下&#= 28216;均起作用；
= 3. 无方向性；
= 4. 对启动子的影响无严格的专一性= 2290;
作用机理：目前已知增强子与蛋= 333;质= 因子结合后能改变染色质的结构。
含义：
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（三）反式作用= 因子
  <= /span>（trans-acting factor）
•定&#= 20041;：能直接或间接识别和= ;结合在顺式作用元件上，调控= ;靶基因表达的蛋白质因子，也称为转录因子（transcripti= onal factor，TF）。 =
•        = ;   蛋白质-DNA，蛋白质-<= /span>蛋白质相互作用（interaction）是其发挥功能的基础。
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反式作用因子的= 类型 <= /div>
1.  基本= 转录因子（通用转录= 2240;子）
       又称TATA盒结合蛋白，如TFⅠ、= TFⅡ= 和TFⅢ= 等。
与RNA poly II 相关的基本转录= 因子
转录因子
功能        = ;         
= TF Ⅱ= A
稳定= TFⅡ= D
促进RNA polyⅡ结合
TF Ⅱ= B
辨认TATA
TF Ⅱ= D
= ATPase
= TF Ⅱ= E
解螺旋酶
= TF Ⅱ= F
促进= TFⅡ= D结合
= TF Ⅱ= -I
唯一的转录因= 子
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•
•
<= b>TFⅡD
<= b>TF ⅡA=
 <= b>TFⅡB=
<= b>RNA polyⅡ<= b>/TFⅡF
<= b>TFⅡE=
PIC
D
<= b>TATA
= B = ;
F=
E=
DNA
转录前起始&= #22797;合物
（P= re-inititation  Complex，PIC）
A=
RNA polyⅡ
基本转录因子（= 通用转录因子）
= TATA
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•   EF1因子        = ;             红细胞
•   Isl-I因子        = ;           胰岛β细胞 <= /span>
•   Myo DI因子        = ;     骨骼肌细胞
•   NF-κB<= /span>因子        = ;     B淋巴细胞 =
•   DF3因子        = ;           乳腺癌细胞        = ;  CEA启动子结合蛋&= #30333;     CEA= = 阳性的肿瘤细胞  =
意义： 不同组= 织细胞发挥不同生理= 1151;= 能的分子基础。
2.  = 2452;织或细胞特异性转录因子
转录因子
组织细胞
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• 热= 0241;克转录因子（HSTF）         高温环境
• cAMP= 效应元件结合蛋白(CREBF)=         cAMP
• 血清应&= #28608;因子（SRF= = ）        = ;     血清中的生长&= #22240;子
• CD28反= 4212;元件结合蛋白        = ;         抗原
• 激活蛋白2(AP-2)        = ;        感染与炎症反应     
意义：机体&= #36866;应内外环境变化的= 998;子基= 础。
3.  = 1487;诱导（inducible）的转录因子
 转录&= #22240;子        = ;             诱导因子
       与= UPS结合的SP1因子= ;CCAAT盒= 转录因子= (CTF);POU蛋白质因&#= 23376;= ;EBP等
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<= ![endif]>
（四）顺式作用= 0803;件与反式作用因子的= 相互作用
=
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  &nb= sp; 基&#= 22240;表达调控是顺式作用元= 件与反式作= 用因子相互作= 用的结果，二者缺一= 9981;可。
反式作用因子必需具= ;备两个条件：
= 1. 与特异顺式作用= ;元件结合的= DNA结合区；
如：螺旋-转角-螺旋；锌指结构；
= 2.  一个&= #25110;多个与其他调控因= 376;结合的区域。
此外，许多转录因子= ;还包含一个介导蛋白<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;font-size:133%'= >质= -蛋白质二聚体化的结= ;构域，如亮氨酸拉= 链，螺旋= = -环= -螺旋。
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&= #65288;五）转录因子&= #19978;的几种重要结构域= —基Ð= 03;&= #65288;motif）
3
.=
.=
.=
.  
1. 螺旋-转角-螺旋（helix-turn-helix，HTH）
       HTH的基&#= 26412;结构是两个α螺= 旋被一个转角结构分开。
        α螺= 旋由短肽链组成，肽链= ;的氨基酸顺序= 因不同的转录因子而= ;不同。
      其中一个α螺旋识别特异的= 顺式作用元件<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;font-size:133%'= >上的= DNA序列，另一个α螺旋&= #21017;结合在= DNA= 上，调控基因的转录= ;。
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1. 螺旋-转角-ś= 46;旋=
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Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
2.  锌= ;指（Zinc finger）
* 某= 0123;= 转录因子的DNA结= 1512;区域成= 指状结构，= 2312;其底= 7096;有2个Cys= 和2个His= ，= 5110;4个Cys 与= 锌离= 3376;螯合= 2290;
•<= span style=3D'font-family:SimSun;mso-fareast-font-family:SimSun;mso-special-for= mat: lastCR;display:none'>
：任一其他
     氨基酸
= C：半胱氨酸
 H：组&= #27688;酸
  Cys2 = / Cys2锌指&= #13;
= Cys2 = / His2锌指&= #13;
见于甾体激素受体
见于SP1，TF Ⅲ= A等
X
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*        = ;  锌指的N-端部分形= 成β折= 叠结构，C-端部分形= 成α螺= 旋结构。
*        = ;   每个α螺旋有&#= 20004;处识别特异的DNA序列；3<= /span>个α螺旋结构与一个<= /b>DNA双螺旋的深沟（major = groove）结合，调控RNA的转录。
*         α螺旋= ;的氨基酸顺序视不同&#= 30340;转录因子而不同。
------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/slide0048.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
N=
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file:///C:/85899A54/14.files/slide0049.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint 演示文稿
3.  亮= ;氨酸拉链（Leu zipper）
*        = ;  蛋白质之间的= 相互作用是生命现象的普遍规律之一，在= ;基因表达调控中= 同样具有重要意义。= ;
*        = ;   亮氨酸拉&#= 38142;是蛋白质二聚体化(<= /span>蛋白质相互作用的一种= ;方式)<= /span>的一种结构基础。
*        = ;    某些癌基因(<= /span>如c-jun<= /b>，v-jun<= /b>，c-= fos，v-fos<= /b>等)<= /span>表达产物通过亮氨酸拉链形成同源或异源二聚= ;体，大大增加对= DNA的结合能力，调控基= ;因表达。
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<= /v:shape>
*        = ;   在亮氨酸拉链= 近N-= 端有富含碱= 4615;(<= /span>带正电荷)<= /span>氨基酸残基的区域，= ;是DNA的结合区。
        亮氨酸拉链是一个高亮氨酸组成= ;的α= 螺旋，每两个螺圈出= 现一个亮氨酸，形成<= span style=3D'font-family:SimHei;mso-fareast-font-family:SimHei;font-size:150%'= >拉链的一边。
         两个蛋白质因= 子的α螺旋通过亮氨酸的疏水= 作用结合在一起形成拉链结构
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&n= bsp;
亮氨酸拉链
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Content-Type: application/javascript; charset="us-ascii" function LoadSld() { var sld=3DGetObj("SlideObj") if( !g_supportsPPTHTML ) { =09 sld.style.visibility=3D"visible" return } if( MakeNotesVis() ) return runAnimations =3D _InitAnimations(); =09 if( IsWin("PPTSld") ) parent.SldUpdated(GetSldId()) g_origSz=3DparseInt(SlideObj.style.fontSize) g_origH=3Dsld.style.posHeight g_origW=3Dsld.style.posWidth g_scaleHyperlinks=3D(document.all.tags("AREA").length>0) if( g_scaleHyperlinks ) InitHLinkArray() if( g_scaleInFrame||(IsWin("PPTSld") && parent.IsFullScrMode() ) ) document.body.scroll=3D"no" _RSW() if( IsWin("PPTSld") && parent.IsFullScrMode() ) FullScrInit(); =09 MakeSldVis(); ChkAutoAdv() if( runAnimations ) { if( document.all("NSPlay") ) document.all("NSPlay").autoStart =3D false; if( sld.filters && sld.filters.revealtrans ) setTimeout( "document.body.start()", sld.filters.revealtrans.duration * = 1000 ); else document.body.start(); } } function MakeSldVis()=20 { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans )=09 { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply()=09 } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis()=20 { if( !IsNts() ) return false=20 SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) {=20 nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.filter !=3D ""; } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii numSlds ) 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g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"放映结束，单击= ;鼠标退出。", SCREEN_MODE=3D"Frames", gIsEndS= how=3D0, NUM_VIS_SLDS=3D43, SCRIPT_HREF=3D"script.js", FULLSCR_HREF=3D"full= screen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0002.htm",1,-1,1),new hrefList(= "slide0003.htm",1,-1,1),new hrefList("slide0007.htm",1,-1,1),new hrefList("= slide0052.htm",1,-1,1),new hrefList("slide0053.htm",1,-1,1),new hrefList("s= lide0054.htm",1,-1,1),new hrefList("slide0006.htm",1,-1,1),new hrefList("sl= ide0008.htm",1,-1,1),new hrefList("slide0009.htm",1,-1,1),new hrefList("sli= de0010.htm",1,-1,1),new hrefList("slide0011.htm",1,-1,1),new hrefList("slid= e0012.htm",1,-1,1),new hrefList("slide0013.htm",1,-1,1),new hrefList("slide= 0014.htm",1,-1,1),new hrefList("slide0015.htm",1,-1,1),new hrefList("slide0= 016.htm",1,-1,1),new hrefList("slide0017.htm",1,-1,1),new hrefList("slide00= 18.htm",1,-1,1),new hrefList("slide0019.htm",1,-1,1),new hrefList("slide002= 0.htm",1,-1,1),new hrefList("slide0021.htm",1,-1,1),new hrefList("slide0022= .htm",1,-1,1),new hrefList("slide0023.htm",1,-1,1),new hrefList("slide0033.= htm",1,-1,1),new hrefList("slide0031.htm",1,-1,1),new hrefList("slide0034.h= tm",1,-1,1),new hrefList("slide0035.htm",1,-1,1),new hrefList("slide0036.ht= m",1,-1,1),new hrefList("slide0037.htm",1,-1,1),new hrefList("slide0038.htm= ",1,-1,1),new hrefList("slide0039.htm",1,-1,1),new hrefList("slide0040.htm"= ,1,-1,1),new hrefList("slide0041.htm",1,-1,1),new hrefList("slide0042.htm",= 1,-1,1),new hrefList("slide0043.htm",1,-1,1),new hrefList("slide0044.htm",1= ,-1,1),new hrefList("slide0045.htm",1,-1,1),new hrefList("slide0046.htm",1,= -1,1),new hrefList("slide0047.htm",1,-1,1),new hrefList("slide0048.htm",1,-= 1,1),new hrefList("slide0049.htm",1,-1,1),new hrefList("slide0050.htm",1,-1= ,1),new hrefList("slide0051.htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"下一步",sPrev=3D"上一步",s= End=3D"结束放映",sFont=3D"宋体",sArrow= =3D"箭头",sFreeform=3D"任意形状",sRect= =3D"矩形",sOval=3D"椭圆" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; s.fontFamily=3DsFont s.fontSize=3D"9pt" s.paddingLeft=3D2 } function CreateSeparator( node ) { var sObj=3DCreateItem( node ) SetCMBorder(sObj,"menu","menu") var s=3DsObj.style s.borderTopColor=3D"threedshadow" s.borderBottomColor=3D"threedhighlight" s.height=3D1 s.fontSize=3D"0px" } function CreateItem( node ) { var elem=3DPPTSld.document.createElement("DIV") node.insertBefore( elem ) return elem } function SetCMBorder( o,ltClr,rbClr ) { var s=3Do.style s.backgroundColor=3D"menu" s.borderStyle=3D"solid" s.borderWidth=3D1 s.borderColor=3DltClr+" "+rbClr+" "+rbClr+" "+ltClr } ------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/fullscreen.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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------=_NextPart_01C48430.EEC41120 Content-Location: file:///C:/85899A54/14.files/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
 &#= 22791;注
大纲
= = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
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